Researchers from Southern Medical University and affiliated organizations assessed the molecular mechanisms behind TGF-β-induced fibrosis in ovarian endometrioma.

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disorder in need of new treatment options. Inhibition of the phosphoinositide 3-kinase δ (PI3Kδ) pathway has shown efficacy in animals with experimental encephalomyelitis (EAE), a model of MS.

Epithelial ovarian cancer (EOC) is the most predominant histologic type of ovarian cancer, with about 55% of patients at an advanced stage when diagnosed; overall survival remains poor.

Interius Biotherapeutics Inc. has been granted Human Research Ethics Committee (HREC) approval and clinical trial notification clearance by Australia’s Therapeutic Goods Administration (TGA) to begin a first-in-human trial of INT-2104, its lead in vivo CAR candidate for treatment of B-cell malignancies.