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BioWorld - Sunday, March 29, 2026
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Cardiovascular

Astrazeneca patents new CX3CR1 antagonists for heart failure

May 9, 2024
Astrazeneca AB has disclosed CX3C chemokine receptor 1 (CX3CR1; CMKBRL1; GPR13) antagonists reported to be useful for the treatment of heart failure, among others.
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Antibody-drug conjugate
Cancer

BL-M11D1 shows antitumor activity in AML xenograft models

May 9, 2024
Researchers from Sichuan Baili Pharmaceutical Co. Ltd. and Systimmune Inc. presented preclinical data for the novel CD33-targeting antibody-drug conjugate (ADC) being evaluated for the treatment of hematologic malignancies.
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Microscope with beakers and flasks
Drug design, drug delivery & technologies

Avicenna extends machine learning platform to enhance medicinal chemistry

May 9, 2024
Avicenna Biosciences Inc. has introduced an extension to its machine learning (ML) technology platform to enhance medicinal chemistry and expedite clinical-stage drug discovery.
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DNA in drug capsules, digital background
Drug design, drug delivery & technologies

Grant funds vehicles to deliver DNA-encoded therapeutics

May 9, 2024
Nanite Inc. has been awarded a $1.8 million grant by the Bill & Melinda Gates Foundation to design and optimize polymeric delivery vehicles to deliver DNA-encoded therapeutics.
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Test tube, dropper
Cancer

MS-8535 is epigenetic SPIN1 inhibitor

May 9, 2024
Researchers from the Icahn School of Medicine at Mount Sinai and affiliated organizations presented the discovery and preclinical characterization of MS-8535, a novel spindlin-1 (SPIN1) inhibitor being developed as chemical tool anticancer agent.
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Glass globe
Infection

Global health fund supports projects for malaria, neglected diseases

May 9, 2024
The Global Health Innovative Technology (GHIT) Fund has announced a total investment of approximately ¥1.64 billion (US$10.8 million) in four projects for the development of new drugs for malaria and neglected tropical diseases.
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Close-up of elderly eye
Biomarkers

Genetic variation in METTL23 gene tied to normotensive glaucoma

May 9, 2024
Recent findings discovered a mutation in the METTL23 gene, which encodes methyltransferase-like protein 23, in a pedigree of normal-tension glaucoma (NTG). The aim of researchers from the Institute for Vision Research, The University of Iowa Roy J and Lucille A Carver College of Medicine was to confirm an association of mutations in this gene with NTG.
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Infection

MRX-5 to treat Mycobacterium abscessus infections

May 9, 2024
New treatment options for treating Mycobaterium abscessus infections are needed. Previous findings had identified the leucyl-tRNA synthetase inhibitor MRX-6038 to have significant activity against M. abscessus. The aim of this new study was to focus on the activity of MRX-5, the oral prodrug of MRX-6038, both in vivo and in vitro.
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Concept art for prenatal genetic testing and whole genome sequencing.
Genetic/congenital

ASGCT: In utero interventions can prevent organ damage after birth

May 9, 2024
By Mar de Miguel
“Prenatal therapies are the next disruptive technologies in health care, which will advance and shape the future of patient care in the 21st century,” said Graça Almeida-Porada, a professor at the Fetal Research and Therapy Center of the Wake Forest Institute for Regenerative Medicine in Winston-Salem, North Carolina. At the American Society of Gene & Cell Therapy (ASGCT) annual meeting in Baltimore on May 5, 2024, Almeida-Porada introduced the first presentation of the scientific symposium “Prospects for Prenatal Gene and Cell Therapy.”
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Diagnostics

Asieris Pharmaceuticals discovers new fluorescence imaging agents for bladder cancer diagnosis

May 8, 2024
Asieris Pharmaceuticals Co. Ltd. has described indole phthalocyanine compounds acting as fluorescence imaging agents with high contrast reported to be useful for the diagnosis of bladder cancer.
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