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BioWorld - Monday, April 6, 2026
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Close up of hand scratching arm with psoriasis patches
Biomarkers

BAG3 protein is present in serum from patients with psoriasis

May 16, 2024
Due to the systemic nature of psoriasis, there is high risk for progressive severe forms of the disease.
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Cancer tumor in breast illustration
Biomarkers

TRIM2 predicts poor survival in patients with TNBC on chemotherapy

May 16, 2024
Breast cancer is a heterogenous disease in terms of its prognosis and treatment response. Metabolic reprogramming is a potential therapeutic target because of its repercussion on oncogenesis.
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Nephrology

Glis2 targeting suppresses cyst formation in polycystic kidney disease models

May 16, 2024
Researchers from Yale School of Medicine, Ionis Pharmaceuticals Inc. and the National Institutes of Health have published data from a study that aimed to identify the signaling pathways involved in cilia-dependent cyst activation (CDCA) in autosomal dominant polycystic kidney disease (ADPKD).
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Art concept for gene therapy research
Genetic/congenital

Decades of studies on gene and cell therapies lead to ASGCT hits

May 16, 2024
By Mar de Miguel
The success of a vaccine, a gene editing design for an untreated disease, or achieving cell engraftment after several attempts, comes from years of accumulated basic science studies, thousands of experiments, and clinical trials. Innumerable steps precede hits in gene and cell therapies before a first-time revelation, and most of them are failures at the time. At the 27th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) in Baltimore last week, several groups of scientists presented achievements that years ago looked impossible.
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Art concept for vaccine for cancer
Immuno-oncology

DNA, mRNA, peptides, cells … everything’s possible in cancer vaccines

May 15, 2024
By Mar de Miguel
Immunotherapy-based cancer vaccines could permanently kill tumors by stimulating immune cells in multiple ways. At the 27th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), researchers presented their advances in this field with different techniques in the scientific symposium “Novel nucleic acid and cell-based vaccines for cancer,” organized by the infectious diseases and vaccines committee.
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Bispecific antibodies with heavy chain in green and pink, light chain in blue and yellow
Cancer

Aiming for complement activation, Commit launches with €16M

May 15, 2024
By Nuala Moran
Newco Commit Biologics ApS has arrived on the scene after raising €16 million (US$17.2 million) in a seed round to advance bispecific antibodies that are designed to activate the complement system and direct it to selectively kill cancer cells.
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Cancer

Simcere Zaiming Pharmaceutical discloses fused heterocyclic aromatic hydrocarbon compounds

May 15, 2024
Simcere Zaiming Pharmaceutical Co. Ltd. has identified kinesin-like protein KIF18A inhibitors reported to be useful for the treatment of cancer.
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Neurology/psychiatric

Beijing Tide Pharmaceutical reports new orydalmine derivatives

May 15, 2024
Beijing Tide Pharmaceutical Co. Ltd. has described orydalmine derivatives reported to be useful for the treatment of pain, depression, and substance abuse and dependence.
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Cancer

USP1 inhibitors for cancer identified by Impact Therapeutics

May 15, 2024
Impact Therapeutics (Shanghai) Inc. has disclosed ubiquitin carboxyl-terminal hydrolase 1 (USP1) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Pfizer patents CDK2/4/6 inhibitors for cancer

May 15, 2024
Pfizer Inc. has divulged cyclin-dependent kinase 2 (CDK2), 4 (CDK4) and 6 (CDK6) inhibitors reported to be useful for the treatment of cancer.
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