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Transparent skull with colorful brain illustration
Cancer

Hemogenyx shows chimeric bait receptor can be delivered into the brain via programmed microglial cells

Feb. 19, 2024
The company has developed a method of transplantation of human hematopoietic stem cells that allows their engraftment and differentiation into microglial cells.
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Colonoscopy illustration showing endoscope, polyps in colon
Cancer

Drug used in cocaine addiction halts colorectal cancer growth

Feb. 19, 2024
Researchers at the University of Ottawa have reported on the use of vanoxerine as a suppressor of CSC tumorigenic activity in preclinical models of colorectal cancer.
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Liver organoid
Cancer

Vidac's VDA-1275 shows promise in mouse and organoid models of solid tumors

Feb. 19, 2024
Vidac Pharma Holdings plc has released promising results for VDA-1275 in mouse cancer and human cellular organoid models of solid tumors, with VDA-1275 showing efficacy as a monotherapy and synergistic effects in combination with sorafenib and cisplatin.
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Hematologic

CBP/p300 HAT domain inhibitor rapidly expands blood leukocyte compartment in vivo

Feb. 19, 2024
In a recent study, researchers from Technische Universität Dresden and affiliated organizations evaluated the novel small-molecule inhibitor of the CBP/p300 HAT domain, A-485, as a potential therapeutic candidate for the treatment of hematological cancers and other pathologies related to blood leukocyte compartment.
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Cross section of brainstem
Infection

AAAS 2024: Chemo brain, other conditions provide lens for long COVID

Feb. 19, 2024
By Nuala Moran
The biological processes giving rise to the central nervous system symptoms of long COVID remain a mystery. But multiple studies suggest they do not appear to be a result of a direct viral infection of brain tissue. The latest such research, which appeared online in Nature Neuroscience on Feb. 16, 2024, demonstrated that local immune response in brain tissues persisted long after SARS-CoV-2 virus had disappeared.
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Other news to note for Feb. 16, 2024

Feb. 16, 2024
Additional early-stage research and drug discovery news in brief, from: Ampio, Vaxxinity.
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Musculoskeletal

Genescience Pharmaceuticals discovers new cannabinoid CB2 receptor agonists

Feb. 16, 2024
Genescience Pharmaceuticals Co. Ltd. has described cannabinoid CB2 receptor agonists reported to be useful for the treatment of arthritis, systemic lupus erythematosus, inflammatory bowel disease, allergic contact dermatitis, colitis, autoimmune diseases and pain.
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Cancer

Insilico Medicine presents new CBL-B inhibitors for cancer

Feb. 16, 2024
Insilico Medicine IP Ltd. has divulged E3 ubiquitin-protein ligase CBL-B (CBLB) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Shanghai Sinotau Biotech describes new FAP-1 inhibitors for cancer

Feb. 16, 2024
Shanghai Sinotau Biotech Co. Ltd. has identified tyrosine-protein phosphatase non-receptor type 13 (PTPN13; FAP-1; PTP-1E) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Betta Pharmaceuticals divulges new EGFR mutant inhibitors for cancer

Feb. 16, 2024
Betta Pharmaceuticals Co. Ltd. has synthesized EGFR (HER1; erbB1) mutant inhibitors reported to be useful for the treatment of cancer.
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