Deeplake Pharmaceuticals (Shandong) Co. Ltd. has patented oxazolo- or thiazolo-indole compounds acting as xanthine dehydrogenase/oxidase (XDH; XOR) and/or solute carrier family 22 member 12 (SLC22A12; URAT1) dual inhibitors. They are reported to be useful for the treatment of gout and hyperuricemia.
The University of California has reported new azocino[4,5,6-cd]indoles acting as 5-HT2A receptor agonists and thus potentially useful for the treatment of neurological and psychiatric disorders.
Tyra Biosciences Inc. has disclosed new indazole compounds acting as fibroblast growth factor receptor (FGFR) inhibitors. They are reported to be useful for the treatment of cancer and developmental disorders.
China Pharmaceutical University has prepared and tested sphingomyelin phosphodiesterase (SMPD1; aSMase) inhibitors potentially useful for the treatment of cancer, autoimmune disease, chronic obstructive pulmonary disease (COPD), Alzheimer’s disease, depression, diabetes, hepatic steatosis and stroke, among others.
Although physiological immune responses require increased tissue vasculature, many solid tumors simultaneously activate angiogenesis to meet the increasing demand for oxygen and nutrients while excluding immune cells. The exact molecular mechanisms by which cancer cells control this immune-refractory angiogenic process remain widely unclear.
Antimicrobial resistance (AMR) is increasingly compromising the effectiveness of essential antibiotics, resulting in higher global mortality and morbidity rates. Despite this urgent need, few new antibiotics, particularly against gram-negative bacteria, are in development.
Gelmedix Inc. has completed a $13 million seed financing to support progression of the company’s lead program, GMX-101, a retinal pigment epithelial (RPE) cell therapy to treat late-stage geographic atrophy.
Fibroblast growth factor receptor 2 (FGFR2) is a transmembrane tyrosine kinase that regulates signaling pathways controlling cell survival and proliferation. Dysregulation of FGFR2, through amplification or activating mutations, contributes to tumor development, making it an attractive target for therapeutic intervention in oncology.
Nektar Therapeutics Inc. has established an academic research collaboration with the University of California, San Francisco (UCSF) to explore the role of tumor necrosis factor receptor 2 (TNFR2) agonism in models of multiple sclerosis (MS) with the aim of supporting progression of NKTR-0165, Nektar’s first-in-class TNFR2 agonist antibody.
Omeros Corp. has successfully completed its initial study in nonhuman primates evaluating the efficacy and safety of its Oncotox-AML cancer therapeutic platform for acute myeloid leukemia (AML). Oncotox-AML is an engineered biologic designed to selectively kill both AML blasts and relapse-related leukemia stem cells.
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