DUBLIN – Michael Greve, one of Germany’s most successful internet entrepreneurs and investors, is personally committing €300 million (US$362 million) to building a portfolio of biotechnology firms focused on different aspects of aging. His investment vehicle, Kizoo Technology Capital GmbH, of Karlsruhe, has already provided seed funding to more than a dozen early stage firms. Greve is now ready to invest in follow-on rounds, particularly in four core companies he described as “category openers” in rejuvenation biotech. “We are really super focused, because there are so many things we could do,” he told BioWorld.
Exercise is a powerful way to keep the elderly brain working well, not just in individuals that are healthy, but also in those with neurodegenerative disease. Even individuals with familial Alzheimer’s, though they will develop dementia regardless of whether they exercise or not, will have relatively better cognitive function if they exercise than if they don’t.
Fountain Therapeutics Inc., a California company working to create treatments for age-related diseases, said Khosla Ventures has led a $6 million series A-1 financing of the startup, with participation from Nan Fung Life Sciences, which earlier contributed $5 million to the round.
Australian researchers led by the Garvan Institute of Medical Research in Sydney have compiled the first reference genome database of healthy older Australians, which potentially can predict disease-linked gene variants more accurately than has been previously possible.
How organisms age, and what determines their lifespan, is one of the basic questions of biology. It is also a major area of biopharmaceutical interest. Partly, this is because most people want to delay shuffling off this mortal coil for as long as possible.
Researchers at the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine (KUSM) in Japan have discovered that people ages 110 or longer, the so-called supercentenarians, have elevated blood levels of CD4+ cytotoxic T lymphocytes (CTLs).
Two very different roles were reported for the protein REST last week. In adults, REST activation appeared to extend lifespan by reducing overall brain activity. Principal investigator Bruce Yankner, professor of genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging, told BioWorld that in postmortem brain samples of individuals who had had no cognitive impairments at the time of their death, his team found "a correlation between down-regulation of excitation and extended longevity."
Telomerase's reputation is that it has an important role in maintaining the ability of stem cells to divide through maintaining telomeres, the structures at the tips of chromosomes that shorten with each replication cycle.
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