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BioWorld - Saturday, June 7, 2025
Home » Topics » Disease categories and therapies » Aging

Aging
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Alteogen’s Altos nabs ₩24.5B in series B to develop new eye drug

July 9, 2024
By Marian (YoonJee) Chu
Altos Biologics Inc., founded as an eye disease-focused subsidiary of Alteogen Inc. in 2020, raised ₩24.5 billion (US$17.7 million) in a series B financing round to advance its pipeline of therapeutics for eye-related conditions, including age-related macular degeneration (AMD). Daejeon, South Korea-based Alteogen said July 9 that the funds raised will be funneled to develop OP-01, Altos’ candidate therapy for AMD.
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Tree in the shape of human head losing leaves
Neurology/psychiatric

Anew Medical advancing Klotho gene therapy program for neurodegenerative disorders

July 9, 2024
Anew Medical Inc. has announced plans to advance its Klotho gene therapy program for neurodegenerative disorders. Initial data suggest that maintaining elevated levels of Klotho in the body significantly contributes to longer, healthier life spans, while individuals with depleted or lower than normal levels of Klotho are more susceptible to neurodegenerative disorders.
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Illustration of a senescent cell
Aging

Senescent cells are essential beyond aging

June 27, 2024
By Mar de Miguel
Senescence is a hallmark of aging, and senescent cells have a reputation to match. They are ‘zombie cells,’ sort of dead themselves but alive enough to poison their surroundings through senescence-associated secretory phenotype (SASP). The reality, though, is more complex.
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Illustration of thymus in relation to lungs and thyroid
Immune

Fibrobiologics’ artificial thymus organoid restores immune function in SCID mouse model

June 26, 2024
Fibrobiologics Inc. has announced the development of a novel artificial thymus organoid that can restore immune function in a severe combined immunodeficiency (SCID) mouse model.
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IPO puzzle pieces

China’s Ascentage drafts confidential IPO for dual listing in US

June 25, 2024
By Marian (YoonJee) Chu
Suzhou, China-headquartered Ascentage Pharma Group Corp. Ltd. has filed plans for a confidential IPO to the U.S. SEC for a potential dual listing on both the U.S. and Hong Kong stock exchanges. News of the U.S. IPO came just a few days after Ascentage drew a $75 million equity investment from Osaka, Japan-headquartered Takeda Pharmaceutical Co. Ltd. with the issuance of about 24.3 million shares at a purchase price of HK$24.09 (US$3.08) per share.
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Martin Tolar, CEO, Alzheon

Alzheon nabs $100M in series E to advance oral Alzheimer’s drug

June 20, 2024
By Marian (YoonJee) Chu
Alzheon Inc. has raised $100 million in a series E financing round to push its oral drug candidate for early Alzheimer’s disease (AD), ALZ-801 (valiltramiprosate), through a late-stage, Apolloe4 study.
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Novosis Excelos Inject

Cgbio plans US entry of Novosis Putty, presents Novosis study

May 20, 2024
By Marian (YoonJee) Chu
After Novosis Putty gained U.S. FDA breakthrough device designation of bio-fusion spine implantation device, South Korea’s Cgbio Co. Ltd. posted positive findings of similar ceramic bone graft, Novosis, to lay groundwork for U.S. market entry.
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Person trying to stop hands on clock
Aging

Seragon Biosciences reports preclinical findings with antiaging candidate

May 8, 2024
Seragon Biosciences Inc. has completed a preclinical study with its novel antiaging candidate, SRN-901. This pivotal study in mice evaluated the impact of SRN-901 on aging as well as various health markers.
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Silhouette of head and brain with DNA double helixes
Neurology/psychiatric

Two copies of APOE4 cause genetic form of Alzheimer’s

May 6, 2024
By Anette Breindl
Based on its analysis of a large cohort of individuals homozygous for the ε4 variant of apolipoprotein E (APOE4), a multinational team of researchers is arguing that homozygosity for APOE4 should be considered a genetic form of Alzheimer’s disease. However, not everyone agrees that the findings warrant reclassifying APOE from risk factor to causal gene. Currently, APOE4 is classified as the strongest risk factor for developing AD. Another variant, the APOE2 variant, is protective, while APOE3 is neutral.
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Neurology/psychiatric

Two copies of ApoE4 cause genetic form of Alzheimer’s

May 6, 2024
By Anette Breindl
Based on its analysis of a large cohort of individuals homozygous for the ε4 variant of apolipoprotein E (ApoE4), a multinational team of researchers is arguing that homozygosity for ApoE4 should be considered a genetic form of Alzheimer’s disease (AD).
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