Curve Therapeutics Ltd. has raised £40.5 million (US$51.2 million) in a series A round to take two lead programs toward the clinic over the next three years. Since its formation in 2019, Curve has applied its Microcycle intracellular screening platform to discover a pipeline of small molecules against oncology targets that have evaded conventional approaches.
A study led by scientists at Victor Chang Cardiac Research Institute in Sydney, Australia, has shown that the transcription factor hypoxia-inducible factor 1 (HIF-1) suppresses harmful reactive oxygen species (ROS)-induced growth of cardiac fibroblasts (CFs) and fibrotic scarring after myocardial infarction (MI) in knockout (KO) mice.
William Kaelin, Peter Ratcliffe, and Gregg Semenza have jointly won the 2019 Nobel Prize "for their discoveries of how cells sense oxygen," the Nobel Assembly at Karolinska Institutet announced today.
