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BioWorld - Friday, December 26, 2025
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Home » Full analysis: Astrazeneca reports 76% efficacy for COVID-19 vaccine
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Full analysis: Astrazeneca reports 76% efficacy for COVID-19 vaccine

March 25, 2021
By Nuala Moran
LONDON – After the extraordinary public accusation by the National Institute of Allergy and Infectious Diseases that it published “outdated” information on the interim results of the phase III U.S. trial of its COVID-19 vaccine, Astrazeneca plc has rushed through the full primary analysis, showing 76% efficacy in preventing symptomatic disease. That is 3% lower than the headline figure in the interim data published on March 22. But with the confidence interval ranging from 68%-82%, it is consistent with the pre-specified interim analysis claim of 79% efficacy – and would appear to indicate the data safety monitoring board’s (DSMB) concern that the company, “may have provided an incomplete view,” was misplaced.
BioWorld Clinical Coronavirus Vaccine

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