Recent studies have shown that up-regulation of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) was able to induce fetal hemoglobin synthesis in human primary erythroblasts.
In mammals, the disruptor of telomeric silencing 1-like (DOT1L) is the only methyltransferase that catalyzes the mono-, di- and tri-methylation of histone H3 at lysine 79 (H3K79). The DOT1L/H3K79me is involved in several relevant physiological and pathological mechanisms, including several viral infections.
The activation of hepatic stellate cells (HSCs) is a key process in the pathogenesis of liver fibrosis, but the molecular mechanisms behind it are not fully understood. By combining the analysis of differentially expressed gene screening of HSC transcriptome and weighted gene coexpression network analysis of liver tissue, researchers searched for transcription factors involved in liver fibrosis.
G protein-coupled receptor kinase 2 (GRK2) is a crucial kinase that has been shown to interact with multiple signaling molecules under different pathological conditions, including fibrosis.
Colorectal cancer (CRC) is rated as the second most deadly cancer after lung cancer. Identifying new mechanisms responsible for CRC pathogenesis is crucial for the development of new therapies.
Prior work has unveiled increased levels of inosine monophosphate dehydrogenase 2 (IMPDH2) expression correlating with tumor progression and poor prognosis in several diseases. A team of researchers in China have now aimed to study IMPDH2’s role in hepatoblastoma.
Pregnane X receptor (PXR) is a transcription factor that plays a crucial role in maintaining bile acid homeostasis by regulating major metabolizing enzymes and transporters.
Acute kidney injury (AKI) is a common disease with high morbidity that still lacks effective drug treatments. The death of tubular epithelial cells is the principal basis for AKI. This cell death in AKI does not occur by necrosis but by other cell death mechanisms such as pyroptosis, among others. Recent findings have implicated chromodomain Y-like (CDYL) in autosomal dominant polycystic kidney disease, but its role in AKI has not been established.
Recurrent spontaneous abortion (RSA), also known as recurrent miscarriage, is a disorder related to pregnancy defined as two or more pregnancy losses during the first trimester. It affects about 2%-5% of couples trying to conceive. Chinese researchers have investigated the potential involvement of Cbl proto-oncogene like 1 (CBLL1) in RSA, since CBLL1 has been reported to vary with the menstrual cycle in the endometrium.
Researchers from Shanghai Jiao Tong University presented data from a study that aimed to assess the role of long intergenic non-protein coding RNA 1605 (LINC01605) in the progression of pancreatic ductal adenocarcinoma (PDAC).
