Among the mechanisms causing calcific aortic valve disease (CAVD) are mitochondrial dysfunction and immune cell infiltration, but it is not well understood just how they impact CAVD pathogenesis.

The reticulon 4 (Nogo) family, which is located in the endoplasmic reticulum, consists of several members including Nogo-A, Nogo-B and Nogo-C. Since previous studies have linked Nogo-B to multiple metabolic processes, researchers from University of Science and Technology of China (USTC) and affiliated organizations investigated the role of Nogo-B in cholesterol metabolism and related metabolic diseases.

Protein homeostasis is disrupted in response to an uncontrolled stress condition, a hallmark of many diseases, such as cataracts. Lens protein accumulation and aggregates are a cause of cataract development.

Investigators at Nanjing Medical University and The University of Texas MD Anderson Cancer Center recently published data from their research that aimed to identify novel immunotherapy targets in triple-negative breast cancer (TNBC).

Investigators at Wuxi No. 2 Peoples Hospital and affiliated organizations conducted studies to identify novel effective biomarkers for early-stage pediatric respiratory syncytial virus (RSV) infection (EPR).