In a new study, researchers from Harvard Medical School and Regulus Therapeutics Inc. further investigated the role of miR-155 in Alzheimer's disease (AD).
Asialoglycoprotein receptor 1 (ASGR1) is a transmembrane protein specifically expressed in hepatocytes that plays a key role in maintaining circulating glycoprotein homeostasis.
Researchers from the Center of Biomedical Research (Lucknow) presented data from a study that assessed the functional significance the translocation of the regulator of G protein signaling 6 (RGS6) to the nucleus in response to cytotoxic stress.
Scientists from Sun Yat-sen University Cancer Center (SYSUCC) and affiliated organizations have reported data from a study that assessed the role of discs large-associated protein 5 (DLGAP5) in lung adenocarcinoma (LUAD).
Researchers from Nanjing University and affiliated organizations have published the outcomes of a study that aimed to investigate the role of cadherin 4 (CDH4) in the metastatic cascade of papillary thyroid cancer (PTC).
Scientists from First Affiliated Hospital Bengbu Medical College and affiliated organizations have studied the role of the RNA-binding ubiquitin ligase MEX3C in lung adenocarcinoma (LUAD).
Heart failure with preserved ejection fraction (HFpEF) has limited treatment options and remains a medical challenge. HFpEF is characterized by diastolic dysfunction with a normal ejection fraction. Previous findings have shown that inhibiting histone deacetylase 6 (HDAC6) alters the mechanisms contributing to dilated cardiomyopathy.
PARP inhibitors such as olaparib are used for the treatment of metastatic castration-resistant prostate cancer (mCRPC) harboring homologous recombination deficiency (HRD), but a proportion of these patients do not respond to therapy or eventually develop resistance.
Researchers have identified NIMA-related kinase 1 (NEK1) as a potential therapeutic target driving tumor growth. It was identified using Turbine Ltd.’s Simulated Cell platform when they simulated perturbations in the DNA damage response pathways. NEK1 is involved in DNA damage response, cell cycle and mitosis.
Researchers from Nanjing Medical University presented data from a study that aimed to investigate the role of amphiregulin (AREG) in activating intestinal fibroblasts and driving fibrogenesis.
