Keeping you up to date on recent developments in oncology, including: New test lends insight into aggressiveness of prostate cancer, could reduce biopsy; Loss of cell polarity is lung cancer precursor; A different path to specificity for Ras inhibitors; Thin films for detection, calibration of proton beams.
A study led by Chinese radiologists at Peking University in Beijing has shown that positron emission tomography imaging of intercellular adhesion molecule-1 (ICAM-1) expression is a predictor for the abscopal effect, whereby nonirradiated cancers respond to radiotherapy.
Keeping you up to date on recent developments in cardiology, including: Fibroblast growth factor a marker for left ventricular hypertrophy in dialysis patients; Consortium updates endpoints for aortic valve studies; ‘Reclip,’ surgery square off for patients with failed mitral valve repair.
Keeping you up to date on recent developments in neurology, including: Fast brainwave oscillations identify, localize epileptic brain; Sleep biomarkers linked to neurodegenerative disease; Autophagy chaperone targets aggregation-prone proteins.
Keeping you up to date on recent developments in diagnostics, including: AI-based model to triage brain MRIs; Tiny light probes enhance brain imaging; Predicting natural menopause age.
A team led by researchers at the Institute of Bioelectronic Medicine at The Feinstein Institutes for Medical Research, the research division of New York’s Northwell Health, developed a long-term implant model for vagus nerve stimulation (VNS) in mice that enables study of bioelectronics in chronic disease. The research was published in Elife, with a full description of the surgical technique and methods for calibrating the stimulation dose to enable other labs to use the methods to advance bioelectronic medicine.
Keeping you up to date on recent developments in orthopedics, including: 3D biomaterial used as 'sponge' for stem cell therapy to reverse arthritis; New biomaterial regrows blood vessels and bone, RCSI research; Without major changes, gender parity in orthopedic surgery will take two centuries.
Keeping you up to date on recent developments in oncology, including: Research may enable real-time imaging of tumors during PBT treatments; Algorithm may restore raw mammograms from processed images; Hand-held device would check for PSA.
Keeping you up to date on recent developments in cardiology, including: PCI still the treatment of choice for COVID-positive STEMI patients; Utility of risk scores for TAVR patients questioned; Plaque similarly predictive in women and men.
Organoids cultured from patient-derived colorectal cancer cells have been used to demonstrate for the first time that tumors which have developed resistance to the full range of existing treatments, across chemotherapies, targeted therapies and immunotherapies, retain a requirement for Werner helicase (WRN) for survival. WRN has a key role in the maintenance of genome stability, but although loss of WRN is known to initiate synthetic lethality in DNA mismatch repair deficient colorectal cancer, studies into the effect of inhibiting that helicase have to date been limited to a handful of cell lines.