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BioWorld - Tuesday, July 5, 2022
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Bioworld MedTech’s Neurology Extra for Dec. 27, 2019

Dec. 27, 2019
By Andrea Applegate and Anette Breindl
No Comments
Keeping you up to date on recent developments in neurology.
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Brain

Breaching all three meninges improves drug delivery to brain

Dec. 27, 2019
By Anette Breindl
No Comments
A single injection of SOD1-targeting RNA into the subpial space, which is below the innermost meningeal layer, was able to spread throughout the spinal cord and, via retrograde delivery, into brain centers that project to the spinal cord in several animal models, including primates.
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Bacteria in petri dishes
The art of war?

By spying on quorum sensing, immune system picks its battles?

Dec. 27, 2019
By Anette Breindl
No Comments
“Bacteria often only do harm at certain concentrations,” Stefan Kaufmann told BioWorld. In fact, bacteria have evolved an entire communication system, so-called quorum sensing, to monitor how many of their colleagues are in the vicinity, and then switch from growth to virulence only at high densities.? 
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Lungs

Bench Press for Dec. 27, 2019

Dec. 27, 2019
By Anette Breindl
No Comments
Scientists at the University of Tuebingen have identified a network of antifibrotic RNAs, and showed that this network was controlled by the transcription factor Pparg. Fibrosis, which is essentially the formation of inappropriate scar tissue, contributes to multiple diseases, and its molecular mechanisms are poorly understood.
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Bioworld MedTech’s Oncology Extra for Dec. 24, 2019

Dec. 24, 2019
By Mark McCarty and Anette Breindl
No Comments
Keeping you up to date on recent developments in oncology.
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Brain
Spot on

Breaching all three meninges improves drug delivery to brain

Dec. 24, 2019
By Anette Breindl
No Comments
A single injection of SOD1-targeting RNA into the subpial space, which is below the innermost meningeal layer, was able to spread throughout the spinal cord and, via retrograde delivery, into brain centers that project to the spinal cord in several animal models, including primates.
Read More
DNA illustration
APOE has secrets left

Large datasets, good statistics allow disease-agnostic SNP discoveries

Dec. 24, 2019
By Nuala Moran
No Comments
LONDON – While large-scale biobanks that link genomics to longitudinal health records of diagnosis, treatment and outcomes promise to revolutionize the understanding of the genetics of complex disease, the detailed statistical analysis of those high-dimensional data is still very much in its infancy.
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Scientists report insights into the mechanics, literally, of IPF

Dec. 24, 2019
By John Fox
No Comments
A Chinese study has established a previously unknown direct mechanistic link between elevated mechanical tension caused by impaired alveolar regeneration and progressive idiopathic pulmonary fibrosis (IPF), highlighting a pathogenic mechanism that may underlie fibrosis.
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Duke researchers develop bone repair-accelerating bandage

Dec. 23, 2019
By Annette Boyle
No Comments
Researchers at Duke University have developed a bandage that concentrates adenosine at the site of a fracture and speeds bone repair. In animal testing, the bandage accelerated bone healing by 20% to 25%, lead researcher Shyni Varghese told BioWorld MedTech.
Read More
APOE has secrets left

Large datasets, good statistics allow disease-agnostic SNP discoveries

Dec. 23, 2019
By Nuala Moran
No Comments
LONDON – While large-scale biobanks that link genomics to longitudinal health records of diagnosis, treatment and outcomes promise to revolutionize understanding of the genetics of complex disease, the detailed statistical analysis of those high-dimensional data is still very much in its infancy.
Read More
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