A Chinese multi-omics analysis of the largest triple-negative breast cancer (TNBC) database compiled to date has identified three new distinct TNBC metabolic-pathway-based subtypes (MPSs), which could be targeted therapeutically.
Researchers at the Feinstein Institutes for Medical Research, the research arm of New York-based Northwell Health, illuminated the precise pathway from the brainstem to the spleen that controls inflammation in a study published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS). Essentially, the work demonstrates how scientists could use the vagus nerve to hack the immune system, enabling them to turn down the excessive response that underlies autoimmune disease without the use of biologics or immunosuppressive drugs.
Keeping you up to date on recent developments in orthopedics, including: Rapid recovery protocol can lead to increased range of motion after TKA; Study compares racial disparities in unilateral vs. bilateral knee replacement surgery; Botox for TMJ disorders may not lead to bone loss in the short term.
BioWorld looks at translational medicine, including: Reversal of pumping direction is reversal of fortune for tumor cells; Cholesterol drug affects checkpoint blockade via MHC1; Heart development protein has role in adult immunity.
"RNA was long thought to be an 'undruggable' target for small molecules, because most cellular RNAs have extensive secondary structure, but only limited tertiary structure," Matthew Disney told BioWorld Science.
Keeping you up to date on recent developments in oncology, including: Blood test does well in distinguishing between malignant, benign growths; PARP inhibition can assist tumor cells; CDK 4/6 inhibitors affect transcriptional landscape.
Single-cell genomic analysis has shown that mutations in the KRAS oncogene co-opt a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells, initiating pancreatic ductal adenocarcinoma, Chinese researchers reported in the November 3, 2020, edition of Nature Cancer.
Keeping you up to date on recent developments in cardiology, including: What is causing COVID-19 blood clots?; Using machine learning to predict survival rates with OHCA; Remote cardiac rehabilitation proves itself.
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