Researchers at Harvard Medical School and The Banner Alzheimer's Institute have identified a potential protective variant that appears to have delayed the onset of clinical symptoms by several decades in one individual with a presenilin mutation. Presenilin mutations cause an autosomal dominant, early onset form of AD that usually leads to clinically noticeable cognitive impairments in one's 40s.
Preclinical animal and cellular models are notoriously bad at predicting drug candidate toxicity in humans. Animal biology is often fundamentally different on this front than in humans, while cells in the lab can't be counted on routinely to replicate the bodily response.
A subtype of schizophrenia is related to abnormally high brain levels of hydrogen sulfide (H2S), which has important implications for the development of new treatments, according to a study by researchers at the RIKEN Center for Brain Science (CBS) in Japan.
A subtype of schizophrenia is related to abnormally high brain levels of hydrogen sulfide (H2S), which has important implications for the development of new treatments, according to a study by researchers at the RIKEN Center for Brain Science (CBS) in Japan.
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