Stimulator of interferon genes (STING) is a protein that senses DNA in the cytosol, where it comes from either an infectious invader or a damaged nucleus and sets off an immune response that ultimately results in the activation of T cells. STING agonists are among the strategies that have been tested in hopes they would increase the response rate to checkpoint blockade. Now, back-to-back papers in the Aug. 21, 2020, issue of Science have detailed the preclinical development of orally available STING agonists.
A Sino-U.S. collaborative study has demonstrated that acupuncture regulates inflammation by activating pro- or anti-inflammatory signaling pathways, while mitigating cytokine storms in mice with systemic inflammation, the study authors reported in the Aug. 12, 2020, edition of Neuron. The study also found that the acupuncture site, intensity and timing determined how it affected response, which has important implications for acupuncture use in inflammatory diseases and as adjunctive cancer therapy.
Keeping you up to date on recent developments in orthopedics, including: Simultaneous stimulation helped a spinal cord injury patient regain the ability to walk; Researchers identify better classification system for adult idiopathic scoliosis; Mixing silk with polymers could lead to better biomedical implants.
A Sino-U.S. collaborative study has demonstrated that acupuncture regulates inflammation by activating pro- or anti-inflammatory signaling pathways, while mitigating cytokine storms in mice with systemic inflammation, the study authors reported in the Aug. 12, 2020, edition of Neuron.
Keeping you up to date on recent developments in oncology, including: New and less expensive approach to digital PCR may improve cancer detection; Stromal cell subtypes identified in TNBC; Microbiome metabolites as immunotherapy adjuvants; Pandemic significantly impeded breast cancer follow-up.
Keeping you up to date on recent developments in cardiology, including: Assessing stroke risk via metabolic syndrome; Under pressure; While less deadly, atrial fibrillation still raises concerns.
A Sino-U.S. collaborative study has demonstrated that acupuncture regulates inflammation by activating pro- or anti-inflammatory signaling pathways, while mitigating cytokine storms in mice with systemic inflammation, the study authors reported in the Aug. 12, 2020, edition of Neuron.
BioWorld looks at translational medicine, including: Oxygen therapy harms lungs via lung, gut microbiome; Turning flexibility into toxicity; Gaining insights into loss of function; Stromal cell subtypes identified in TNBC.
Keeping you up to date on recent developments in neurology, including: Combining genetic information with EMRs to pinpoint childhood epilepsies; AI-enhanced precision medicine identifies novel autism subtype; From variants to treatments in neurology.
Triggering receptor expressed on myeloid cells 2 (TREM2) was first discovered because variants affect the risk of developing late-onset Alzheimer’s disease (AD).
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