BioWorld looks at translational medicine, including: Vascular endothelial cells active co-conspirators in metastasis; Targeted delivery improves checkpoint blockade.

Researchers working at the Jackson Laboratory Cancer Center reported in the September 21, 2020, issue of Nature Immunology that breast cancer cells induced neutrophils to accumulate lipids, which were transported to metastatic tumor cells through a macropinocytosis pathway, thus fueling the metastatic potential of tumor cells with lipids.

BioWorld looks at translational medicine, including: Myelin regulatory factor helps out pancreatic cancer cells.

A U.S.-led international whole-exome sequencing study has discovered that mutations in genes encoding for the growth of the neurites necessary for neural connectivity increase the risk for cerebral palsy, the authors reported in the September 28, 2020, edition of Nature Genetics.

Researchers at the University of Virginia have used a retrospective database analysis to show that the use of nucleoside reverse transcriptase inhibitors for the treatment of HIV or hepatitis B reduced the risk of developing type 2 diabetes by 33%.

Using 3D tumor organoids, researchers have added to existing evidence that inhibition of kinesin spindle protein (KSP) may represent a broadly relevant target for the treatment of the aggressive childhood tumor neuroblastoma.