Stimulating the innate immune system with defective viral genomes (DVG)-based strategy provided broad-spectrum protection against RNA viral infections, including SARS-CoV-2 and other respiratory diseases in animal models, according to a U.S.-led international collaborative study reported in the Nov. 17, 2021, edition of Cell.
Targeting the epigenetic histone modifier BMI-1 in B cells restored effective humoral immune responses to control chronic viral infection in mice, according to new multicenter Australian study led by immunologists at Monash University in Melbourne, Victoria.
Investigators have identified a previously unrecognized population of senescent cells, called p21high cells, in fat tissue and demonstrated their contributory role in metabolic dysfunction, obesity, insulin resistance and type 2 diabetes.
“I was not always someone who would have advertised probiotics,” Michael Otto told BioWorld. And it’s easy to see why. At this point, probiotics are more often dubious wellness offerings than evidence-based therapeutics. Part of the issue is that the mechanisms by which probiotics are supposed to exert their effects are mostly vague. Molecular mechanisms that could account for claimed health benefits are few and far between. But Otto, who is chief of the pathogen molecular genetics section at the National Institutes of Allergy and Infectious Disease, and his colleagues have identified one such molecular mechanism.
A newly developed antibody-based treatment and a protein-based vaccine for Alzheimer's disease (AD) have both been shown to reduce AD symptoms in mouse models of the disease, British and German researchers reported in the November 15, 2021, edition of Molecular Psychiatry.
Immune system B cells secrete the neurotransmitter gamma amino-butyric acid (GABA), which promotes generation of anti-inflammatory macrophages and blunts the cytotoxic T cell-based response to tumors in mice.
Immune system B cells secrete the neurotransmitter gamma amino-butyric acid (GABA), which promotes generation of anti-inflammatory macrophages and blunts the cytotoxic T cell-based response to tumors in mice.
Aligos Belgium presented research on ALG-005398, a first representative of a series of non-heteroaryldihydropyrimidines (HAPs) class I capsid-assembly modulators, that was identified using structure-based drug design and scaffold hopping.
A study led by scientists at Victor Chang Cardiac Research Institute in Sydney, Australia, has shown that the transcription factor hypoxia-inducible factor 1 (HIF-1) suppresses harmful reactive oxygen species (ROS)-induced growth of cardiac fibroblasts (CFs) and fibrotic scarring after myocardial infarction (MI) in knockout (KO) mice.
A newly developed messenger RNA vaccine is the first such approach to elicit acquired resistance against the tick Ixodes scapularis and prevent it from transmitting the Lyme disease vector Borrelia burgdorferi in guinea pigs, according to a U.S. study led by researchers at Yale University School of Medicine in New Haven, Conn.
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