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Brophenexin and aliudanexin

Exciting toxicity study implicates TRMP4 in NMDA-mediated cell death

Oct. 9, 2020
By Anette Breindl
Investigators at the University of Heidelberg have identified a previously unknown mechanism for excitotoxicity and used their insight to identify “unconventional neuroprotectant” compounds that could prevent cell death and reduce brain damage in a mouse model of stroke.
Read More
Capsid and HIV genome
Bench Press

Test tube HIV enables replication insights

Oct. 9, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Fat-free mice have bigger bones.
Read More
Leukemia illustration

CNS leukemia cells depend on fat enzyme to survive and grow

Oct. 9, 2020
By Subhasree Nag
A multi-institutional team of researchers has discovered that acute lymphoblastic leukemia cells metabolically adapt to the cerebrospinal fluid-filled CNS microenvironment upon migration from the bone marrow with alterations in fatty acid synthetic pathways.
Read More

BioWorld MedTech’s Diagnostics Extra for Oct. 8, 2020

Oct. 8, 2020
By Meg Bryant
Keeping you up to date on recent developments in diagnostics, including: Improving sensitivity of COVID-19 tests; Deep learning algorithm helps triage suspected COVID-19 cases; Cancer image analysis tool incorporates HER2 biomarker assay.
Read More
Bacteria in mouse small intestine
Bench Press

Microbiome metabolite affects neuropathic pain

Oct. 8, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Prying the BBB back open for improved LSD treatment.
Read More

BioWorld MedTech’s Orthopedics Extra for Oct. 7, 2020

Oct. 7, 2020
By Holland Johnson
Keeping you up to date on recent developments in orthopedics, including: LED-based UV irradiation safely prevents the loss of bone and muscle mass in mice; Coupling antibiotics with stem cells to fight off bone infections; Study: Unnecessary stress testing performed prior to knee and hip replacement surgeries.
Read More
Nobel Prize in Chemistry illustration
Three’s a crowd

Doudna-Charpentier duo is sole winner of chemistry Nobel

Oct. 7, 2020
By Anette Breindl
Surprising no one, Jennifer Doudna and Emmanuelle Charpentier won the 2020 Nobel Prize in Chemistry “for the development of a method for genome editing,” that is, the CRISPR/Cas9 system.
Read More
Tumor necrosis factor (TNF), a cytokine involved in inflammation processes
Bench Press

Immunocytokines jumpstart anti-glioblastoma immunity

Oct. 7, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Following neonatal lead enables spinal cord repair in mice.
Read More
DNA

Inflammatory response gene identified in sepsis

Oct. 7, 2020
By John Fox
A whole-genome clustered regularly interspaced short palindromic repeats (CRISPR) screening study is the first to identify the gene regulating the inflammatory response and immune cell death during sepsis, Australian researchers reported in the October 5, 2020, edition of Nature Immunology.
Read More

BioWorld MedTech’s Oncology Extra for Oct. 6, 2020

Oct. 6, 2020
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology, including: New data cast doubt on post-resection radiotherapy for NSCLC; Carcinogens need not be mutagens; Myelin regulatory factor assists pancreatic cancer cells; Deepmedic provides glioblastoma segmentation with sparsified data.
Read More
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