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Blood cell, test tubes, dropper

Gut microbe enzymes can produce universal donor blood cells

May 3, 2024
By Nuala Moran
Researchers have identified enzymes in gut microorganisms that could cleave A and B antigens from red blood, transmuting them to O negative cells.
Read More
Colorful illustration of the heart
Cardiovascular

Human iPSCs restore muscle, function in monkeys with heart failure

May 3, 2024
By Tamra Sami
Japanese researchers have transplanted human induced pluripotent stem cells (iPSCs) in a primate model of myocardial infarction and were able to restore heart muscle and function in monkeys. Developed by Tokyo-based Heartseed Inc., the grafted iPSCs consist of clusters of purified heart muscle cells (cardiomyocyte spheroids) that are injected into the myocardial layer of the heart. Published in Circulation on April 26, 2024, the study showed that the cardiomyocyte spheroids survived long term and showed improved contractile function with low occurrence of post-transplant arrhythmias.
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X/Y chromosomes
Immune

X chromosome silencer contributes to female autoimmune risk

April 29, 2024
By Anette Breindl
Females have a much greater risk of developing an autoimmune disease than males do. Eighty percent of autoimmune disease patients are female, and specific disorders can have an even more lopsided ratio – 90% of systemic lupus erythematosus (lupus) and almost 95% of Sjögren’s disease patients are female.
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Lung cancer driven by the Kras oncogene shown in purple

Broader KRAS inhibition methods include chaperoning, gluing, vaccinating

April 24, 2024
By Anette Breindl
The existence of two approved therapies, Lumakras (sotorasib, Amgen Inc.) and Karzati (adagrasib, Mirati Therapeutics Inc.), has been a triumphant success against KRAS, a protein that was once considered undruggable.
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Macrophage and cancer cell
Cancer

Pancreatic cancer cells' interaction with macrophages induces cachexia

April 22, 2024
By Mar de Miguel
Cross-talk between macrophages and tumor cells could modulate cachexia in pancreatic cancer patients. A group of scientists from the University of Oklahoma has discovered a new pathway that promoted muscle wasting after the recruitment of this immune cell in the tumor microenvironment, activating cachexia-inducing factors.
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Macrophage and cancer cell
Cancer

Pancreatic cancer cells' interaction with macrophages induces cachexia

April 19, 2024
By Mar de Miguel
Cross-talk between macrophages and tumor cells could modulate cachexia in pancreatic cancer patients. A group of scientists from the University of Oklahoma has discovered a new pathway that promoted muscle wasting after the recruitment of this immune cell in the tumor microenvironment, activating cachexia-inducing factors. Macrophage depletion and the inhibition of this signaling could be developed as a therapeutic target for this condition.
Read More
Illustration of cancer cells entering the bloodstream.
Cancer

AACR 2024: New concepts suggest new targets for metastatic disease

April 16, 2024
By Anette Breindl
Prior to this year’s Annual Meeting of the American Association for Cancer Research (AACR), it had been 14 years since metastasis had been the subject of a plenary session. So, the Tuesday session on “Evolution of the genome, microenvironment, and host through metastasis” had plenty of new insights to share.
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Illustration of cancer cells entering the bloodstream.
Cancer

AACR 2024: New concepts suggest new targets for metastatic disease

April 10, 2024
By Anette Breindl
Prior to this year’s Annual Meeting of the American Association for Cancer Research (AACR), it had been 14 years since metastasis had been the subject of a plenary session. So, the Tuesday session on “Evolution of the genome, microenvironment, and host through metastasis” had plenty of new insights to share.
Read More
Image of clock over dna strands
Cancer

AACR 2024: Getting older younger may be driving rise in early-onset cancers

April 8, 2024
By Anette Breindl
As with most common diseases of the developed world, aging is the major risk factor for developing cancer. Most of the half-dozen hallmarks of precancer that were published last week by investigators from Vanderbilt University and the Fred Hutchinson Cancer Research Center are also hallmarks of aging. Unfortunately, scientists reported at the American Association for Cancer Research’s (AACR) 2024 annual meeting this week that accelerated aging is increasing, and may be driving an increase in early-onset cancers.
Read More
Illustration of head with maze that is missing parts
Neurology/Psychiatric

Better drugs for neurodegeneration will take more research, better biomarkers

April 5, 2024
By Anette Breindl
At a recent meeting on “Research priorities for preventing and treating Alzheimer’s disease and related dementias” (ADRD), convened by the National Academies, one consensus priority on ADRD research was that there needs to be more of it at every stage. Several speakers presented stark numbers on the relative volume of research in cancer and neurodegeneration. Research output, measured in peer-reviewed papers, for dementia is estimated to be around 10,000 papers annually, compared to 150,000 for cancer, while AD clinical trials are also few and far between compared to cancer trials. This final installment of BioWorld’s series on Alzheimer’s explores some of the reasons for this discrepancy along with the latest advances and ongoing efforts to accelerate research and drug development in the field.
Read More
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