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Kelin Zhao and Daniel Gray
Aging

Discovery of new age-related epithelial cells sheds light on aging in the thymus

Aug. 23, 2024
By Tamra Sami
Researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne have discovered new cells that drive the aging process in the thymus that could unlock a way to restore function and prevent immunity from waning as we age. The thymus is the first organ in the body to shrink as people age. As this happens, the T-cell growth areas in the thymus are replaced with fatty tissue, diminishing T-cell production and contributing to a weakened immune system.
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Gamma secretase protein complex
Neurology/psychiatric

Presenilin mutations kill neurons, no amyloid-β required

Aug. 23, 2024
By Mar de Miguel
Scientists at Harvard Medical School have shown that in mice lacking amyloid beta (Aβ), the fundamental hallmark of Alzheimer's disease (AD), neurons died from the effect of the most harmful mutation of this neurodegenerative disease. They showed that presenilin (PS) could be behind the origin of the disease without the need for Aβ. They maintain that it is time to update theories and redirect efforts.
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Illustration of male vs. female bodies showing organs
Endocrine/metabolic

Female sex hormones, adiposity are bad mix in multiple sclerosis

Aug. 21, 2024
By Anette Breindl
The risk of developing multiple sclerosis (MS) is nearly four times as high for women as it is for men. And that relative risk has increased sharply over time. In 1955, women were only slightly more likely than men to develop MS. A research team at the University of Toronto and the Oklahoma Medical Research Foundation (OMRF) has gained new insights into possible causes for this increasing disparity.
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Coronavirus, lungs, hand holding stethoscope
Respiratory

Scientists discover gene associated with recovery responses in severe respiratory viral infections

Aug. 20, 2024
By Tamra Sami
Researchers have identified a gene associated with whether patients hospitalized with respiratory viral infections recover rapidly or face life-threatening complications. The gene has the potential to be used as a diagnostic tool or biomarker, which could help triage patients suffering from severe respiratory infections. Having such a biomarker would help clinicians in their early risk assessments to manage their intervention strategies.
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Illustration of influenza virus replication complex with chicken, cow, human, seal wireframe drawings
Infection

Structural study gives insights into influenza virus species jumps

Aug. 20, 2024
By Anette Breindl
“There are hundreds of strains of bird flu, and most of them don’t infect humans, or even mammals,” Stephen Cusack told BioWorld. “There are two main reasons for that.” To be able to cause an infection, a virus “has to be able to get into the cell, and for that it needs a receptor,” Cusack said. For influenza viruses, those receptors are hemagglutinin receptors, and they differ in subtle but important ways between birds and mammals.
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Photo of jellyfish in aquarium lit by blue light
Aging

Jellyfish genes rejuvenate intestinal stem cells in fruit flies

Aug. 13, 2024
By Tamra Sami
Researchers in Japan were able to transfer genes from jellyfish into common fruit flies and discovered that the transferred gene suppressed an age-related intestinal issue in the flies. The findings suggest that studying genes specific to animals with high regenerative capability like jellyfish may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.
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Illustration of Toxoplasma gondii tachyzoites
Drug design, drug delivery & technologies

Parasite could deliver therapeutic proteins to the brain

Aug. 13, 2024
By Mar de Miguel
Infection or cure? Scientists from Tel Aviv University and the University of Glasgow genetically modified the Toxoplasma gondii to bring a protein inside neurons. The novelty of using a protozoan that can travel from the gut to parasitize the CNS contrasts with the possibility of causing a disease. The scientists are already working on how to avoid it.
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Illustration of HIV cell entry
HIV/AIDS

Treating HIV with defective, thieving HIV

Aug. 13, 2024
By Mar de Miguel
A strategy inspired by deficient HIV replication could be used as a treatment to reduce viral load in patients living with HIV and help control the pandemic of the retrovirus. Scientists from the University of California San Francisco want to use HIV against itself by using a parasitic version of the pathogen.
Read More
Illustration of ovaries and uterus with endometriosis
Obstetrics

(Modest) funding increases bring endometriosis discovery impetus

Aug. 9, 2024
By Nuala Moran
After decades of being woefully under-diagnosed and all but ignored by the biotech and pharma industry, recent advances in understanding its complex etiology could be opening the way to new treatments for endometriosis. Impetus is coming from (modest) increases in funding for basic research, such as the Biden administration’s $200 million for women’s health research and NIH grants under an ‘Advancing cures and therapies and ending endometriosis diagnostic delays’ call announced in March of this year.
Read More
Illustration of Toxoplasma gondii tachyzoites
Drug design, drug delivery & technologies

Parasite could deliver therapeutic proteins to the brain

Aug. 8, 2024
By Mar de Miguel
Infection or cure? Scientists from Tel Aviv University and the University of Glasgow genetically modified the Toxoplasma gondii to bring a protein inside neurons. The novelty of using a protozoan that can travel from the gut to parasitize the CNS contrasts with the possibility of causing a disease. The scientists are already working on how to avoid it.
Read More
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