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AI-generated image for cancer cells observed under a microscope

Lung macrophages put invasive breast cancer cells to sleep

Oct. 15, 2024
By Xavier Bofill Bruna
Breast cancer cells, when disseminated to other secondary organs such as the lungs, may stay in a dormant state for years, even decades. But the mechanisms that limit their expansion are not well understood. This is what researchers call a dormant mesenchymal-like phenotype before metastasis to the lungs. Now, scientists have shown in a study published Oct. 7, 2024, in Cell, that the limiting of disseminated breast cancer cells (DCCs) to metastasize in the lungs is due to alveolar macrophages, which activate signals that make DCCs stay dormant.
Read More
Illustration of proteins and year they were developed
Drug design, drug delivery & technologies

Chemistry Nobel awarded for 3D protein design, prediction work

Oct. 15, 2024
By Mar de Miguel
David Baker, Demis Hassabis and John Jumper share the 2024 Nobel Prize in Chemistry for their contributions to the science of protein structure. David Baker was awarded half the prize “for computational protein design,” according to the Royal Swedish Academy of Sciences. Hassabis and Jumper shared the other half “for protein structure prediction.”
Read More
Clostridium difficile bacteria

A novel mRNA-LNP vaccine facilitates Clostridioides difficile control

Oct. 11, 2024
By Coia Dulsat
Clostridioides difficile has been traditionally isolated from health care facilities' inpatients, but it is increasingly being identified in people who have not recently been hospitalized and is more and more found in community settings. Investigators from Perelman School of Medicine at University of Pennsylvania have developed an mRNA-LNP vaccine with promising results in preventing and controlling C. difficile infection.
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Visualization of protein folding process
Drug design, drug delivery & technologies

Protein design: if you can’t find ’em, make ’em

Oct. 10, 2024
By Mar de Miguel
David Baker, director of the Institute for Protein Design at the University of Washington School of Medicine, is a pioneer in protein design. His contributions have been recognized with countless awards, and now, a place among the 2024 Clarivate Citation Laureates.
Read More
Illustration of proteins and year they were developed
Drug design, drug delivery & technologies

Chemistry Nobel awarded for 3D protein design, prediction work

Oct. 9, 2024
By Mar de Miguel
David Baker, Demis Hassabis and John Jumper share the 2024 Nobel Prize in Chemistry for their contributions to the science of protein structure. David Baker was awarded half the prize “for computational protein design,” according to the Royal Swedish Academy of Sciences. Hassabis and Jumper shared the other half “for protein structure prediction.”
Read More
Illustration of 2024 Nobel Prize in Physics winners John Hopfield and Geoffrey Hinton

2024 Physics Nobel goes for foundations of AI

Oct. 8, 2024
By Anette Breindl
It’s hard to know where to start in describing the biopharma applications of the 2024 Nobel Prize in Physics. It was awarded to John Hopfield and Geoffrey Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”
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Illustration of Victor Ambros and Gary Ruvkun
Biomarkers

Two win Nobel for microRNA work

Oct. 8, 2024
By Mar de Miguel
Research into the regulation of gene expression experienced a significant breakthrough with the discovery of microRNA, small RNA molecules that do not code for proteins but control their translation. This finding has earned its discoverers – Victor Ambros and Gary Ruvkun – the 2024 Nobel Prize in Physiology or Medicine “for the discovery of microRNA and its role in post-transcriptional gene regulation.”
Read More
Visualization of protein folding process
Drug design, drug delivery & technologies

Protein design: if you can’t find ’em, make ’em

Oct. 8, 2024
By Mar de Miguel
David Baker, director of the Institute for Protein Design at the University of Washington School of Medicine, is a pioneer in protein design. His contributions have been recognized with countless awards, and now, a place among the 2024 Clarivate Citation Laureates. Baker’s lab has developed several open-source software applications for nanotechnology and biomedicine. With these methods, scientists build new proteins that bind to drug targets and block them or activate cellular signals.
Read More
Illustration of Victor Ambros and Gary Ruvkun
Biomarkers

Two win Nobel for microRNA work

Oct. 7, 2024
By Mar de Miguel
Research into the regulation of gene expression experienced a significant breakthrough with the discovery of microRNA, small RNA molecules that do not code for proteins but control their translation. This finding has earned its discoverers – Victor Ambros and Gary Ruvkun – the 2024 Nobel Prize in Physiology or Medicine “for the discovery of microRNA and its role in post-transcriptional gene regulation.”
Read More
Adult fly brain 3D reconstruction
Neurology/psychiatric

140,000 cells and 50M synapses make 1 adult fly brain

Oct. 3, 2024
By Mar de Miguel
A collaboration led by the Flywire Consortium and comprising hundreds of scientists has completed a whole map of the adult fruit fly brain after several decades of collaborative work.
Read More
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