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BioWorld - Monday, June 23, 2025
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Photo of jellyfish in aquarium lit by blue light
Aging

Jellyfish genes rejuvenate intestinal stem cells in fruit flies

Aug. 13, 2024
By Tamra Sami
Researchers in Japan were able to transfer genes from jellyfish into common fruit flies and discovered that the transferred gene suppressed an age-related intestinal issue in the flies. The findings suggest that studying genes specific to animals with high regenerative capability like jellyfish may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.
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Illustration of Toxoplasma gondii tachyzoites
Drug design, drug delivery & technologies

Parasite could deliver therapeutic proteins to the brain

Aug. 13, 2024
By Mar de Miguel
Infection or cure? Scientists from Tel Aviv University and the University of Glasgow genetically modified the Toxoplasma gondii to bring a protein inside neurons. The novelty of using a protozoan that can travel from the gut to parasitize the CNS contrasts with the possibility of causing a disease. The scientists are already working on how to avoid it.
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Illustration of HIV cell entry
HIV/AIDS

Treating HIV with defective, thieving HIV

Aug. 13, 2024
By Mar de Miguel
A strategy inspired by deficient HIV replication could be used as a treatment to reduce viral load in patients living with HIV and help control the pandemic of the retrovirus. Scientists from the University of California San Francisco want to use HIV against itself by using a parasitic version of the pathogen.
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Illustration of ovaries and uterus with endometriosis
Obstetrics

(Modest) funding increases bring endometriosis discovery impetus

Aug. 9, 2024
By Nuala Moran
After decades of being woefully under-diagnosed and all but ignored by the biotech and pharma industry, recent advances in understanding its complex etiology could be opening the way to new treatments for endometriosis. Impetus is coming from (modest) increases in funding for basic research, such as the Biden administration’s $200 million for women’s health research and NIH grants under an ‘Advancing cures and therapies and ending endometriosis diagnostic delays’ call announced in March of this year.
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Illustration of Toxoplasma gondii tachyzoites
Drug design, drug delivery & technologies

Parasite could deliver therapeutic proteins to the brain

Aug. 8, 2024
By Mar de Miguel
Infection or cure? Scientists from Tel Aviv University and the University of Glasgow genetically modified the Toxoplasma gondii to bring a protein inside neurons. The novelty of using a protozoan that can travel from the gut to parasitize the CNS contrasts with the possibility of causing a disease. The scientists are already working on how to avoid it.
Read More
Photo of jellyfish in aquarium lit by blue light
Aging

Jellyfish genes rejuvenate intestinal stem cells in fruit flies

Aug. 7, 2024
By Tamra Sami
Researchers in Japan were able to transfer genes from jellyfish into common fruit flies and discovered that the transferred gene suppressed an age-related intestinal issue in the flies. The findings suggest that studying genes specific to animals with high regenerative capability like jellyfish may uncover new mechanisms for rejuvenating stem cell function and extending the healthy lifespan of unrelated organisms.
Read More
Cancer cells
Immuno-oncology

Forcing tumor cells to get with the re-program

Aug. 5, 2024
By Anette Breindl
Cellular immunotherapy is the Lamine Yamal of cancer therapy. It is easy to forget how young the field is – and that as stunning as it is to watch in action already, it is still reaching its full potential. One aspect of doing so is working in a broader range of tumor types. The field made a giant step toward that goal with last week’s approval of Tecelra (afamitresgene autoleucel, Adaptimmune Therapeutics plc), the first CAR T cell to be approved for treatment of a solid tumor.
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CAR T cell attacking cancer cells
Cancer

Removing CD5 'brake' on CAR T cells increases antitumor efficacy

Aug. 2, 2024
By Mar de Miguel
To be successful, CAR T-cells need a balance between being effective and overkill. Researchers from the University of Pennsylvania and Vittoria Biotherapeutics Inc. have eliminated the CD5 signaling pathway of their CAR Ts to prevent the immunosuppressive brake effect. In return, this improved their proliferation and antitumor activity in T cell lymphomas.
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Cross section illustration of HIV virus parts
HIV/AIDS

IAS 2024: Seventh HIV cure reported, but broad reach will take other approaches

July 22, 2024
By Anette Breindl
The 2024 meeting of the International AIDS Society (IAS), which is being held in Munich this week, began with the announcement of another curative bone marrow transplant. The new case brings the total number of patients cured of HIV via a bone marrow transplant up to 7 since “Berlin patient” Timothy Ray Brown became the first such person in 2007.
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Single strand RNA

BIX Korea 2024: Promise of mRNA technology for cell and gene therapy

July 16, 2024
By Marian (YoonJee) Chu
The industry is looking, with renewed hope, to the “promise” of messenger RNA (mRNA) therapeutics for a wide range of diseases beyond COVID-19, and not only in vaccine form but also for gene and cell therapies.
Read More
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