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Illustration of interaction between PD-1 and PD-L1 blocked by therapeutic antibodies

Anti-PD-1 therapy triggers microglia, causing CNS side effects

June 19, 2024
By Mar de Miguel
The adverse effects of PD-1 blockers on the CNS observed in cancer patients could occur through their effects on an enzyme that activates microglia. Pharmacological inhibition of the enzyme in mice reduced microglial activation and cognitive deficit without altering the antitumor capacity of the immunotherapy.
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3D illustration of acute myeloid leukemia cells
Cancer

EHA 2024: Movers and shakers in the AML landscape

June 19, 2024
By Coia Dulsat
During the basic science morning track on the last day of this year’s Annual Congress of the European Hematology Association (EHA), the attention was focused on oncogenic transcription factors and complexes considered turning points within the acute myeloid leukemia (AML) arena.
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AI-generated image of blood cells in a bone marrow biopsy
Hematologic

EHA 2024: Calreticulin is up-and-coming target in myeloproliferative disorders

June 14, 2024
By Coia Dulsat
Myeloproliferative neoplasms (MPNs) can only be cured, to date, using allogeneic stem cell transplantation which, in turn, only works for up to 20% of patients. As calreticulin (CALR) frameshift mutations are the second most common cause of MPNs, targeting this endoplasmic reticulum resident protein is one of the strategies emerging at the forefront of hematological malignancies research.
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Two silhouettes with tangle, gear, spiral

Dissecting post-traumatic stress disorder and depression

May 31, 2024
By Mar de Miguel
Scientists from the PsychENCODE Consortium have analyzed the brain transcriptome in a coordinated series of studies to map all the cell types, genes, epigenetic factors, and molecular pathways involved in different psychiatric disorders. After a first set of projects based on bulk analysis, the second phase of this project included 14 simultaneous publications that revealed the cellular atlas of post-traumatic stress disorder and major depressive disorder, among others.
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Brain and DNA

Brain cell maps, the neurological zoom of psychiatric disorders

May 30, 2024
By Mar de Miguel
Understanding psychiatric disorders at a cellular and molecular level could provide a different perspective to design diagnostic and therapeutic tools searching for the origin of these disorders and the alterations they cause. Fourteen simultaneous studies from the PsychENCODE Consortium have delved into the cellular atlases of human neurodevelopment, reporting the broadest view of neuropsychiatry to date.
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Vaccination

In HIV, vaccine-induced broadly neutralizing antibodies, and paths to more of them

May 22, 2024
By Anette Breindl
In a paper published in the May 17, 2024, online issue of Cell, investigators from the Duke Human Vaccine Institute reported that a sequence of three immunizations in the HVTN-133 trial was sufficient for the development of heterologous or broadly neutralizing antibodies that protected against several strains of HIV.
Read More
Art concept for gene therapy research
Genetic/congenital

Decades of studies on gene and cell therapies lead to ASGCT hits

May 16, 2024
By Mar de Miguel
The success of a vaccine, a gene editing design for an untreated disease, or achieving cell engraftment after several attempts, comes from years of accumulated basic science studies, thousands of experiments, and clinical trials. Innumerable steps precede hits in gene and cell therapies before a first-time revelation, and most of them are failures at the time. At the 27th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) in Baltimore last week, several groups of scientists presented achievements that years ago looked impossible.
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Art concept for vaccine for cancer
Immuno-oncology

DNA, mRNA, peptides, cells … everything’s possible in cancer vaccines

May 15, 2024
By Mar de Miguel
Immunotherapy-based cancer vaccines could permanently kill tumors by stimulating immune cells in multiple ways. At the 27th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT), researchers presented their advances in this field with different techniques in the scientific symposium “Novel nucleic acid and cell-based vaccines for cancer,” organized by the infectious diseases and vaccines committee.
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Vial and syringe with DNA
Ocular

ASGCT: ‘From darkness to light’ in ocular gene therapy

May 14, 2024
By Mar de Miguel
From glaucoma to Stargardt disease, age-related macular degeneration (AMD) to retinitis pigmentosa, or a corneal transplant to Bietti’s crystalline dystrophy, the 27th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) is working to bring some light to patients with age and congenital diseases that affect vision. From May 7-11, 2024, thousands of scientists are gathering in Baltimore to show their advances against the challenges of delivering genes and cells to the correct place, avoiding immunogenicity and improving diseases.
Read More
Vial and syringe with DNA
Ocular

ASGCT: ‘From darkness to light’ in ocular gene therapy

May 10, 2024
By Mar de Miguel
From glaucoma to Stargardt disease, age-related macular degeneration (AMD) to retinitis pigmentosa, or a corneal transplant to Bietti’s crystalline dystrophy, the 27th Annual Meeting of the American Society of Gene & Cell Therapy (ASGCT) is working to bring some light to patients with age and congenital diseases that affect vision. From May 7-11, 2024, thousands of scientists are gathering in Baltimore to show their advances against the challenges of delivering genes and cells to the correct place, avoiding immunogenicity and improving diseases.
Read More
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