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BioWorld - Thursday, June 26, 2025
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Cross section illustration of HIV virus parts
HIV/AIDS

IAS 2024: Seventh HIV cure reported, but broad reach will take other approaches

July 22, 2024
By Anette Breindl
The 2024 meeting of the International AIDS Society (IAS), which is being held in Munich this week, began with the announcement of another curative bone marrow transplant. The new case brings the total number of patients cured of HIV via a bone marrow transplant up to 7 since “Berlin patient” Timothy Ray Brown became the first such person in 2007.
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Single strand RNA

BIX Korea 2024: Promise of mRNA technology for cell and gene therapy

July 16, 2024
By Marian (YoonJee) Chu
The industry is looking, with renewed hope, to the “promise” of messenger RNA (mRNA) therapeutics for a wide range of diseases beyond COVID-19, and not only in vaccine form but also for gene and cell therapies.
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Stem cells

ISSCR 2024: Expanding niche definition gives insights into stem cells

July 15, 2024
By Anette Breindl
The word “niche” implies a specialized environment. But to Fiona Doetsch, the stem cell niche is anything but. For brain stem cells, “the whole organism is the niche,” Doetsch told the audience at the third plenary session of the International Society for Stem Cell Research (ISSCR) annual meeting in Hamburg this week. It’s a surprising idea at first, given the brain’s protection from many circulating substances via a series of barriers, including the blood-brain barrier and the blood-cerebrospinal fluid barrier.
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Illustration demonstrating parts of the ear

A gene therapy could restore hearing in adults

July 12, 2024
By Mar de Miguel
Patients with congenital hearing loss could benefit from a gene therapy currently in development. Although there are approaches that could reverse the process in children and young people before it becomes severe, so far, adults do not have any treatment that prevents the progressive deterioration of auditory sensory cells caused by this disease.
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Single strand RNA

BIX Korea 2024: Promise of mRNA technology for cell and gene therapy

July 10, 2024
By Marian (YoonJee) Chu
The industry is looking, with renewed hope, to the “promise” of messenger RNA (mRNA) therapeutics for a wide range of diseases beyond COVID-19, and not only in vaccine form but also for gene and cell therapies.
Read More
Bridge recombinase mechanism 3D illustration

New techniques open the way for large-scale programmable genome editing

July 2, 2024
By Mar de Miguel
New single-step genome editing techniques that enable the insertion, inversion or deletion of long DNA sequences at specified genome positions have been demonstrated in bacteria.
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Bridge recombinase mechanism 3D illustration

New techniques open the way for large-scale programmable genome editing

June 27, 2024
By Mar de Miguel
New single-step genome editing techniques that enable the insertion, inversion or deletion of long DNA sequences at specified genome positions have been demonstrated in bacteria.
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Illustration of interaction between PD-1 and PD-L1 blocked by therapeutic antibodies

Anti-PD-1 therapy triggers microglia, causing CNS side effects

June 19, 2024
By Mar de Miguel
The adverse effects of PD-1 blockers on the CNS observed in cancer patients could occur through their effects on an enzyme that activates microglia. Pharmacological inhibition of the enzyme in mice reduced microglial activation and cognitive deficit without altering the antitumor capacity of the immunotherapy.
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3D illustration of acute myeloid leukemia cells
Cancer

EHA 2024: Movers and shakers in the AML landscape

June 19, 2024
By Coia Dulsat
During the basic science morning track on the last day of this year’s Annual Congress of the European Hematology Association (EHA), the attention was focused on oncogenic transcription factors and complexes considered turning points within the acute myeloid leukemia (AML) arena.
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AI-generated image of blood cells in a bone marrow biopsy
Hematologic

EHA 2024: Calreticulin is up-and-coming target in myeloproliferative disorders

June 14, 2024
By Coia Dulsat
Myeloproliferative neoplasms (MPNs) can only be cured, to date, using allogeneic stem cell transplantation which, in turn, only works for up to 20% of patients. As calreticulin (CALR) frameshift mutations are the second most common cause of MPNs, targeting this endoplasmic reticulum resident protein is one of the strategies emerging at the forefront of hematological malignancies research.
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