By using an unsupervised machine learning approach to look at genetic variation across the protein-coding genomes of 140,000 species, researchers at Harvard Medical School and Oxford University have developed a new variant classifying system that performed on a par with wet lab approaches.
A study led by researchers at the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, has shown that amygdala kappa-opioid receptor-dependent upregulation of glutamate transporter 1 mediates depressive-like behaviors in mouse models of opiate abstinence.
At a recent lecture at the U.S. National Institutes of Health, Mehta, who is chief of the laboratory of inflammation and cardiometabolic diseases at the National Heart Lung and Blood Institute and an adjunct professor of medicine at George Washington University, described his insights into the links between psoriasis, inflammation and cardiometabolic disease.
By increasing the expression of the chloride transporter Kcc2 (K-Cl cotransporter 2), researchers at Duke University have reduced chronic pain in mouse models of nerve pain and bone cancer.
Attaching a modified bacterial-derived formyl peptide chemoattractant to an antibiotic enhanced recruitment of neutrophils and improved their bactericidal ability in mouse models, according to a study led by European Molecular Biology Laboratory Australia researchers at Monash University in Melbourne.
The Cancer Grand Challenges Mutographs study, a combined genetic and epidemiological analysis of data from eight countries with widely different incidences of esophageal squamous cell carcinomas (ESCC), has unexpectedly failed to identify mutational signatures indicating DNA damage that could account for global ESCC incidence variations.
Sangamo Therapeutics Inc. has reported preclinical results for IL23R-CAR-Tregs, a strategy based on chimeric antigen receptor (CAR)-modified regulatory T cells (Tregs) for the treatment of Crohn's disease.
A multidisciplinary team of scientists led by Britt Adamson at Princeton University along with collaborators from the Massachusetts Institute of Technology, the genome editing company Editas Medicine, and University of California, San Francisco have developed a novel high-throughput screening tool, Repair-seq, to profile mutations at targeted DNA lesions.
In recent years enteric glial cells have moved on from being regarded as bit part players passively supporting intestinal epithelial cells, to being recognized as having a fundamental role in gastrointestinal physiology.
The proinflammatory cytokine macrophage migration inhibitory factor has been demonstrated to drive the induction and progression of spondyloarthritis in mice and to be associated with human disease, according to the findings of an international study led by researchers at the University of Toronto in Ontario, Canada.
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