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Digital cancer cells illustration

New target identified for treatment-resistant CRC

April 14, 2021
By Nuala Moran
Organoids cultured from patient-derived colorectal cancer cells have been used to demonstrate for the first time that tumors which have developed resistance to the full range of existing treatments, across chemotherapies, targeted therapies and immunotherapies, retain a requirement for Werner helicase (WRN) for survival.
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BioWorld MedTech’s Orthopedics Extra for April 14, 2021

April 14, 2021
By Holland Johnson
Keeping you up to date on recent developments in orthopedics, including: X-rays confirm promise of new luminescent markers; Pillar of support: Breakthrough discovery could speed up bone implant recovery; New biosealant can stabilize cartilage, promote healing after injury.
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Stomach and intestine

New agonist MAb resolves chronic inflammation

April 14, 2021
By John Fox
A French study has demonstrated that the novel agonist anti-human ChemR23 monoclonal antibody (MAb) designated OSE-230 accelerated recovery from acute inflammation and triggered resolution of chronic inflammation in mice chronic colitis models, preventing fibrosis and reducing tumor development.
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BioWorld MedTech’s Oncology Extra for April 13, 2021

April 13, 2021
By Mark McCarty
Keeping you up to date on recent developments in oncology, including: NIH drug screening protocol identifies treatment for SCLC; Explanation for DR5 antibody problem surfaces; Location, location, location in avoidance of esophagitis.
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Microbiome illustration

Gut peptide shown to improve metabolic disease in mice

April 13, 2021
By John Fox
A Korean study led by Seoul National University scientists is the first to demonstrate that the human intestinal mucin-degrading bacterium, Akkermansia muciniphila, secretes a glucagon-like peptide-1 (GLP-1)-inducing protein, which significantly improved glucose homeostasis and ameliorated metabolic disease in mice.
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BioWorld MedTech’s Cardiology Extra for April 12, 2021

April 12, 2021
By Mark McCarty
Keeping you up to date on recent developments in cardiology, including: Rheumatic aortic stenosis responds well to TAVR vs. SAVR; Cardiac MR may improve correct diagnosis of left ventricular non-compaction; Better management needed for infarct patients with mechanical complications.
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Cancer research illustration

AACR 2021: Research points to ways to fight cachexia's bite

April 12, 2021
By Anette Breindl
Cachexia, Teresa Zimmers told the audience at the Annual Meeting of the American Association for Cancer Research (AACR), is "woefully understudied for the outsized impact it has on cancer patients." The condition, which is currently defined as weight loss and muscle wasting, is the direct cause of death in an estimated 25% to 30% of cancer patients. But it is the main subject of only 0.1% of research papers and 0.2% of clinical trials.
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BioWorld MedTech’s Neurology Extra for April 9, 2021

April 9, 2021
By Andrea Applegate
Keeping you up to date on recent developments in neurology, including: Blood test for depression, bipolar disorder developed; Specialized hydrogel helps repair circuitry in severe TBI; Using AI to diagnose neurological diseases based on motor impairment.
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BioWorld MedTech’s Diagnostics Extra for April 8, 2021

April 8, 2021
By Meg Bryant
Keeping you up to date on recent developments in diagnostics, including: Method measures vital signs using smartphone camera; Improving purity of urine and plasma cfDNA.
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Neurons

SMN gene therapy can result in too much of a good thing

April 8, 2021
By W. Todd Penberthy
A splicing defect in the survival of motor neuron gene (SMN) leads to a deficiency of protein function that results in spinal muscular atrophy. It is the second most common autosomal recessive disease, occurring with a prevalence of 1 to as little as 6,000 births.
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