BioWorld looks at translational medicine, including: Classifying variants of unknown significance; Platelets release antigenic DNA in lupus; Intracranial samples give glimpse into stroke response.

Researchers at the University of California San Diego (UCSD) have taken wearables to a new level with a soft skin patch that integrates functions currently siloed in continuous glucose monitors, wearables, wellness apps and hospital monitors. The all-in-one patch can be worn on the neck to continuously track blood pressure, heart rate, glucose, lactate, alcohol and caffeine.

Organoids grown from cholangiocytes – the epithelial cells of the bile duct – are poised to be used in ex vivo cell therapy to increase the number of donated livers that are suitable for transplant, and also for direct bile duct repairs.

BioWorld looks at translational medicine, including: Metabolic changes are antibiotic resistance mechanism; Tumor neoantigens can inhibit immune response; Chromosome organization machinery linked to DNA repair.

The molecular mechanisms underlying control of antibiotic production by hormones in soil bacteria have been elicited for the first time in a study by scientists at University of Warwick in Coventry, U.K., and at Monash University in Melbourne, Australia.

Researchers at Thomas Jefferson University have implanted brain electrodes in a patient who suffered a subcortical ischemic stroke more than a year ago to help them overcome abnormal muscle tone and control a robotic arm brace. Artificial intelligence (AI) algorithms interpret neuronal signals recorded by the electrodes into movement of the brace.

A study by researchers at Nanjing University has demonstrated that in mice, depression-like phenotypes induced by paternal stress can be inherited by the offspring through a causal role of microRNAs in the father's sperm.