LONDON – The Google artificial intelligence company Deepmind has developed an algorithm that can predict the 3D structure of a protein from its amino acid sequence, making it possible to solve the structures of proteins, such as G-protein coupled receptors (GPCRs), which are a mainstay of drug targeting but whose structure is challenging to determine with current methods.
Moderna has announced that the primary efficacy analysis of the phase III COVE study of mRNA-1273 conducted on 196 cases has confirmed the high efficacy observed at the first interim analysis (ClinicalTrials.gov Identifier NCT04470427).
Keeping you up to date on recent developments in orthopedics, including: Potential cellular target for eliminating bone breakdown in osteoporosis found; Popular weight-loss surgery in teenagers weakens bones; Study: Early, late stages of degenerative diseases are distinct.
An international study led by Nanyang Technological University in Singapore has designed and synthesized broad-spectrum antimicrobial polymers (AMPs) and demonstrated the safety and efficacy of two such agents against multidrug-resistant (MDR) bacteria in mouse models of sepsis.
The BCL6 degrader BI-3802 works by inducing polymerization of its target protein, which in turn triggers the addition of ubiquitin tags on the polymerized structure and degradation by the proteasome, scientists reported in the Nov. 18, 2020, issue of Nature.
Keeping you up to date on recent developments in oncology, including: Nanoparticles may blunt TRIM37’s impact on metastasis in triple-negative breast cancer; Glycolysis inhibition via collateral lethality; Making exceptional responders unexceptional; Protons may spare cancer patients a hit to the heart.
Keeping you up to date on recent developments in cardiology, including: 3D-printed heart models aim to train future surgeons; Researchers: Digital program lowered patients’ cholesterol, blood pressure; Additional monitoring may be needed for those at risk of atrial fibrillation.
By screening the microbiomes of marine organisms, scientists at the University of Wisconsin have identified nearly 150 potential new antifungal compounds, they reported in the November 20, 2020, issue of Science.
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