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BioWorld MedTech’s Neurology Extra for April 17, 2020

April 17, 2020
By Andrea Applegate and Anette Breindl
Keeping you up to date on recent developments in neurology, including: Gene variant may protect against Alzheimer's; Miniature microscope used to study neural circuit activity in nonhuman primate model; Dopamine has epigenetic role in addiction; Depression’s structural problem.
Read More
CRISPR Cas9 illustration

Making neurons from glia alleviates neurodegenerative diseases

April 17, 2020
By John Fox
Chinese scientists have shown for the first time that the down-regulation of a single RNA-binding protein, polypyrimidine tract-binding protein 1 (Ptbp1), locally converted glial cells to neurons and showed promise for treating the symptoms of neurodegenerative diseases in mice.
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Structure of pyocin R2

Bench Press for April 17, 2020

April 17, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Engineering better bacterial backstabbers; Targeting bystander protein improves sepsis outcome; Long noncoding RNA has sex-specific role in depression; Targeted IL-12 heats up cold tumors; Fast route from fibroblasts to photoreceptors; Eating pro-inflammatory IgG helps prevent liver failure; Depression’s structural problem; Modeling the post-infarct heart; Interleukins rile each other up in reaction to implants; Complement links high BMI to dementia.
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BioWorld MedTech’s Diagnostics Extra for April 16, 2020

April 16, 2020
By Meg Bryant
Keeping you up to date on recent developments in diagnostics, including: CEUS LI-RADS for diagnosing liver cancer; Variations in echocardiography recommendations for patients with S. aureus; Reusable bronchoscopes and COVID-19 patients.
Read More

BioWorld MedTech’s Orthopedics Extra for April 15, 2020

April 15, 2020
By Holland Johnson
Keeping you up to date on recent developments in orthopedics, including: Researchers develop synthetic scaffolds to heal injured tendons, ligaments; Self-powered X-ray detector to revolutionize imaging for medicine, security and research; Opioid prescriptions linked to obesity.
Read More
Keith Ligon, chief of neuropathology, Brigham and Women's Hospital

For gliomas, hypermutated does not mean sensitive to checkpoint blockade

April 15, 2020
By Anette Breindl
The largest study to date on hypermutated gliomas has delivered new insights into their origin, as well as their response to several different treatments. Specifically, even though they are hypermutated, such tumors are unlikely to respond to PD-1 blockers.
Read More
Microneedle array vaccine
Vaccines

The next pandemic: Speeding development and stretching supplies

April 14, 2020
By Anette Breindl
“Vaccines, obviously, are the ultimate solution for pandemics,” Rino Rappuoli told BioWorld. They have, he added, “already eliminated a lot of pandemic threats – smallpox, influenza, poliomyelitis.”
Read More
Natural killer cell
Drugs

The next pandemic: Firebreaks and host-directed therapies

April 14, 2020
By Anette Breindl
Specific therapies against a new disease take time to develop. But there are methods that can speed up that development.
Read More
SARS-CoV-2 molecular diagnostic
Diagnostics

The next pandemic: Excess testing capacity essential, but cost question not yet answered

April 14, 2020
By Mark McCarty
There will be lessons learned aplenty when the COVID-19 pandemic finally breaks, including how serological and molecular testing can be used to maximum effect to corral a future pandemic.
Read More
1918-19 Spanish flu patient, paramedics, ambulance
Surveillance

The next pandemic: Death, taxes and zoonotic spillover

April 14, 2020
By Anette Breindl
“In any crisis, leaders have two equally important responsibilities: solve the immediate problem and keep it from happening again."
Read More
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