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BioWorld - Tuesday, January 31, 2023
Home » Topics » Science » Microbiome

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Illustration representing connection between brain and gut microbiome.
Neurology/Psychiatric

Changes in microbiome impact neurodegeneration in Alzheimer’s model

Jan. 13, 2023
By Helen Albert
No Comments
A study in a mouse model of tau protein build-up in the brain, similar to that seen in later stage Alzheimer’s disease (AD), shows that changes to the microbiome in these animals can impact the degree and progression of neurodegeneration observed. As reported in the Jan. 12, 2023, study published in Science, the researchers found that mice that were germ free and those given antibiotics to change their gut microbiome early in life had significant reductions in brain atrophy compared with those with a standard microbiome.
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Obesity, fat cell research concept image
Endocrine/Metabolic

Rose Biosciences to take forward MCW discovery for obesity

Nov. 15, 2022
No Comments
Medical College of Wisconsin (MCW) has announced the founding of Rose Biosciences, a biotech company pioneering a new approach to obesity treatment based on a discovery at MCW.
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Infection

Covira closes dilutive funding to advance microbiome therapy to prevent postsurgical infections

Oct. 7, 2022
No Comments
Covira Inc., a spinout from The University of Chicago, has closed its first dilutive funding via an oversubscribed $1.0 million seed round after raising $9.1 million of nondilutive funding.
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Cancer

TMAO promotes immune activation and enhances immune checkpoint blockade therapy in PDAC

Oct. 6, 2022
No Comments
Pancreatic ductal adenocarcinoma (PDAC) is a type of cancer with poor prognosis and immunotherapy has failed at improving patient...
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Lungs and bronchiole
Respiratory

Airway microbiome regulates chronic obstructive pulmonary disease

Aug. 30, 2022
By Mar de Miguel
No Comments
A metabolite derived from the airway microbiome, indole-3-acetic acid (IAA), could become a potential therapeutic candidate for chronic obstructive pulmonary disease (COPD). Researchers at South China Normal University (SCNU) have shown how IAA prevents lung function decline by reducing inflammation, apoptosis and emphysema through IL-22 in the interaction between macrophages and alveolar epithelial cells.
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Brain teaser

Carnitine metabolite has role in cognitive aging

Dec. 31, 2021
By Anette Breindl
No Comments
Investigators at the University of Freiburg and Swiss startup Ultimate Medicine have identified a compound produced by the gut microbiome as contributing to age-related cognitive decline by modulating inhibitory synaptic transmission and neural network activity.
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Atmo CEO holding capsule

Atmo raises AU$9.6M to progress ingestible capsule for analyzing the gut microbiome

Sep. 24, 2021
By Tamra Sami
No Comments
PERTH, Australia – Atmo Biosciences Ltd. has closed an oversubscribed AU$9.6 million (US$7 million) capital raise that will allow it to further develop its gas-sensing capsule for monitoring the health of the gut and the microbiome. Until now, there has not been a diagnostic test that can measure gases in the gut in vivo.
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Intestine

Gut bacteria accumulate multiple therapeutic drugs

Sep. 9, 2021
By Nuala Moran
No Comments
The impact that the microbiome has on drug metabolism is further elucidated in new research showing for the first time that bacteria in the gut accumulate and store drug compounds.
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Juvenile king penguin
Vultures and warthogs and bats, oh my!

Israeli startup goes bio(me)-prospecting in wild animals

March 26, 2021
By Anette Breindl
No Comments
The animal world is full of species that can perform astonishing, and sometimes disgusting, feats. Take vultures, for example. “They eat this rotten meat that is full of pathogens and toxins, and they stay healthy,” Neta Raab told BioWorld. Raab is the co-founder and CEO of Wild Biotech Ltd., an Israeli startup that is seeking to understand gut microbiome contributions to these animal superpowers, and harness them for therapeutic use.
Read More
Juvenile king penguin
Vultures and warthogs and bats, oh my!

Israeli startup goes bio(me)-prospecting in wild animals

March 25, 2021
By Anette Breindl
No Comments
The animal world is full of species that can perform astonishing, and sometimes disgusting, feats. Take vultures, for example. “They eat this rotten meat that is full of pathogens and toxins, and they stay healthy,” Neta Raab told BioWorld. Raab is the co-founder and CEO of Wild Biotech Ltd., an Israeli startup that is seeking to understand gut microbiome contributions to these animal superpowers, and harness them for therapeutic use.
Read More
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