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Home » Topics » Science » Microbiome

Microbiome
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Immuno-oncology

Kanvas Biosciences raises funding to advance live biotherapeutic products for cancer patients

July 2, 2024
Kanvas Biosciences Inc. has raised $12.5 million in additional funding to support development of the company’s spatial biology platform and advance two novel therapeutics in its immuno-oncology program, KAN-001 and KAN-003.
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Blood cell, test tubes, dropper

Gut microbe enzymes can produce universal donor blood cells

May 3, 2024
By Nuala Moran
Researchers have identified enzymes in gut microorganisms that could cleave A and B antigens from red blood, transmuting them to O negative cells.
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Blood cell, test tubes, dropper
Hematologic

Gut microbe enzymes can produce universal donor blood cells

May 2, 2024
By Nuala Moran
Researchers have identified enzymes in gut microorganisms that could cleave A and B antigens from red blood, transmuting them to O negative cells. This is “a decisive step forward” in the quest to develop a universal donor blood that can be administered to people of any blood group without eliciting a harmful immune response, according to Maher Abou Hachem of the Technical University of Denmark, who co-led the research.
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Candida albicans infection
Infection

Commensal yeast species prevents candidiasis

March 20, 2024
By Mar de Miguel
Scientists at the Weizmann Institute of Science in Israel announced the discovery of the new intestinal microbiota species Kazachstania weizmannii in mice, which competed with and limited the growth of Candida albicans, thus preventing candidiasis. Both microorganisms belong to the Saccharomycetaceae family and reside in humans, maintaining a complex interaction with therapeutic value.
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Hands holding holographic intestine
Gastrointestinal

Study links microbiome, vitamin B12, tissue repair in ulcerative colitis

Nov. 24, 2023
By Mar de Miguel
A laboratory technique used to generate pluripotent stem cells from any tissue, cellular reprogramming, has led a group of researchers to the discovery of a process that could have an impact on natural tissue repair.
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Lab sample and bone marrow illustration
Immune

Intestinal microbiota have a say in graft-vs-host disease

July 24, 2023
By Mar de Miguel
Avoidance of graft-vs.-host disease (GVHD) after a hematopoietic stem cell transplant could depend on certain members of the microbiome. According to a study led by scientists at the Fred Hutchinson Cancer Center (FHCC), while some species of intestinal bacteria repressed the expression of the major histocompatibility complex II (MHC-II), others induced it and triggered the immune response that produces GVHD.
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Cancer

Microbiome member has sex-specific effects in colorectal cancer

July 21, 2023
By Marian (YoonJee) Chu
Researchers from the Chinese University of Hong Kong have identified the Carnobacterium maltaromaticum bacterium as a potential oral probiotic prophylactic to increase vitamin D production and reinvigorate gut microbiota to prevent colorectal cancer (CRC) in women.
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3D representation of tumor microenvironment
Immuno-oncology

Intron identifies prophage and jamphage from microbiome found in long-term pancreatic cancer survivors

May 30, 2023
Intron Biotechnology Inc. has announced the identification of lysogenic bacteriophages prophage and jamphage in the pancreatic cancer-related microbiome. This identification was achieved as part of the ongoing Phageriarus development project that is focused on acquiring bacteriophage-derived proteins that can serve as immune regulators, with the ultimate goal of developing phage-based immunotherapeutics for immune disorders and cancer.
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Neurology/Psychiatric

Altered gut microbiome contributes to symptoms of anorexia

April 21, 2023
By Helen Albert
Research led by the University of Copenhagen and Herlev-Gentofte University Hospital shows that individuals with the eating disorder anorexia nervosa have an abnormal gut microbiome that likely contributes to symptoms associated with the condition. Published in the April 17, 2023, issue of Nature Microbiology, the study showed multiple differences in the species and amounts of bacteria and viruses present in the gut of people with the condition compared with healthy controls.
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Colon cancer illustration
Cancer

Intron demonstrates inhibition of tumorigenesis using P18-BE3CRC in colorectal cancer organoid model

April 4, 2023
Intron Biotechnology Inc. has demonstrated the effectiveness of P18-BE3CRC using a cancer organoid model.
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