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Home » Topics » Science » Targeted therapy

Targeted therapy
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Illustration of brain in head highlighting the blood-brain barier.
Neurology/psychiatric

Montara secures seed funding for binary brain pharmacology

July 31, 2024
Montara Therapeutics Inc. has received $8 million seed financing from several investors to further its development of its ’binary pharmacology’ for diseases of the brain.
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Piggy bank filled with dollar coins
Endocrine/metabolic

Confo financing will in part bring two compounds to IND

July 29, 2024
G protein-coupled receptor (GPCR) drug discovery and development specialist Confo Therapeutics NV has closed a €60 million (US$65.2 million) series B round that will fund a significant expansion of the inhouse portfolio while it continues to turn the handle on its technology platform to generate more compounds for partnering.
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Nephrology

Glis2 targeting suppresses cyst formation in polycystic kidney disease models

May 16, 2024
Researchers from Yale School of Medicine, Ionis Pharmaceuticals Inc. and the National Institutes of Health have published data from a study that aimed to identify the signaling pathways involved in cilia-dependent cyst activation (CDCA) in autosomal dominant polycystic kidney disease (ADPKD).
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Neurology/Psychiatric

α5 integrin is therapeutic target in amyotrophic lateral sclerosis

Aug. 8, 2023
Researchers from Oregon Health and Science University presented data from a study that aimed to identify and validate potential new therapeutic targets for the treatment of amyotrophic lateral sclerosis (ALS). Systems immunology analysis utilizing mass cytometry (CyTOF) was used to assess α5 integrin expression in 78,293 single cells, including 21,250 CD45+/CD11b+ myeloid cells from CNS of superoxide dismutase-1 (SOD) G93A mouse model of ALS (SOD1G93A).
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Illustration of brain in head highlighting the blood-brain barier.
Cancer

ESMO TAT: Tumor therapies find new ways into the brain, by finesse or force

March 7, 2023
By Anette Breindl
Whether as primary tumors or metastases, brain tumors remain stubbornly intractable to the progress that has occurred in many other tumor types. As Igor Vivanco, who is a senior lecturer in the Institute of Pharmaceutical Science at King’s College London, noted in his talk at the European Society for Medical Oncology Targeted Anticancer Therapies (ESMO TAT) meeting in Paris this week, the last win in glioblastoma was the addition of temozolomide to the radiotherapy standard of care in 2005. And temozolomide’s benefit is measured in months, not years.
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Cross-section of brain
Neurology/Psychiatric

Ifi27l2a identified as new therapeutic target to reduce brain injury in stroke

Feb. 23, 2023
Microglial cells (MGs) are resident immune cells in the brain, which play a key role in the acute response and chronic recovery to stroke. Investigators at the University of Texas Health Science Center Houston aimed to evaluate MG transcriptomic response to stroke in mouse brain.
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Drug R&D concept image.
Respiratory

VGLL3 as novel therapeutic target in fibrosis

Feb. 21, 2023
While it is known that differentiated myofibroblasts produce excessive collagens, which accumulate in tissues and cause hardening, the mechanisms involved in these processes are largely unknown. In a recent study, Kyushu University scientists aimed to assess the molecular mechanisms by which matrix stiffness increases fibrosis-related gene expression in myofibroblasts.
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Blood cells and bacteria
Infection

pCTS-L as new therapeutic target in potentially lethal sepsis

Feb. 15, 2023
Cathepsin L (CTS-L) is a lysosomal enzyme responsible for degrading endocytosed proteins to generate immunogenic antigens for adaptive immunities. In the current study, researchers reported data from a study that aimed to assess the potential of targeting procathepsin L (pCTS-L) as a potential therapeutic strategy against sepsis.
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Dividing breast cancer cell.
Cancer

SULF1 knockdown seen to modulate TNBC metastatic potential

Feb. 15, 2023
Triple-negative breast cancer (TNBC) still remains as one of the most aggressive breast cancer types among women, with high metastatic potential and ability to shift towards epithelial-mesenchymal transition (EMT).
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Immune

IL-2RG blockade as a therapeutic strategy for prevention and treatment of T-cell-mediated disease

Feb. 3, 2023
The interleukin-2 receptor subunit γ (IL-2RG), also known as γc cytokine receptor or CD132, family of cytokines includes interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-21. These γc cytokines exert broad pleiotropic effects on the innate and adaptive immune system, and they all share the IL-2RG chain as part of its signaling receptor complex. Researchers from Regeneron Pharmaceuticals Inc. aimed to assess whether targeting γc cytokines may serve as a strategy for the prevention and treatment of T-cell-mediated disease.
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