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Home » Topics » Science » Vaccines

Vaccines
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HIV-1 virus particle
HIV/AIDS

IAS 2023: Vaccines and broadly neutralizing antibodies bring cure for HIV one step closer

Aug. 1, 2023
By Tamra Sami
Although huge strides have been made with antiretroviral therapy (ART) and prevention since HIV was first reported 42 years ago, there is still not an effective preventive vaccine or a scalable cure for those living with HIV. But broadly neutralizing antibodies (bNAbs) look to be a further step down the pathway to a cure, speakers said during the International AIDS Society meeting held July 23 to 26 in Brisbane, Australia.
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Electron micrograph of red blood cell infected with Plasmodium falciparum surrounded by knobless uninfected blood cells.
Infection

New mRNA malaria vaccine could be more effective than antibody strategies targeting liver memory T cells

July 27, 2023
An mRNA vaccine candidate that acts in the liver by recruiting memory T cells could be the key against malaria, according to a study in mice that demonstrated its efficacy by including a natural killer T (NKT) cell agonist.
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HIV-1 virus particle
HIV/AIDS

IAS 2023: Vaccines and broadly neutralizing antibodies bring cure for HIV one step closer

July 26, 2023
By Tamra Sami
Although huge strides have been made with antiretroviral therapy (ART) and prevention since HIV was first reported 42 years ago, there is still not an effective preventive vaccine or a scalable cure for those living with HIV. But broadly neutralizing antibodies (bNAbs) look to be a further step down the pathway to a cure, speakers said during the International AIDS Society meeting held July 23 to 26 in Brisbane, Australia.
Read More
Neurology/Psychiatric

PRX-123, a dual Aβ/tau peptide vaccine that clears Aβ plaques in brains of AD mice

July 21, 2023
Since both amyloid-β (Aβ) and tau are involved in the progression of Alzheimer’s disease (AD), it is believed that simultaneous disruption of these...
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A person receives the seasonal influenza vaccine.
Infection

MDCK-QIV influenza virus vaccine demonstrates safety and efficacy in preclinical setting

July 21, 2023
Researchers from Wuhan Institute of Biological Products Co. Ltd. and affiliated organizations presented preclinical data for the novel Madin...
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DNA in test tubes
Immune

Evaxion develops genetic adjuvant technology to boost immune response to viral, bacterial and cancer vaccines

May 26, 2023
Evaxion Biotech A/S has unveiled the technology behind its proprietary genetic adjuvant developed to enhance the effectiveness of DNA and mRNA vaccines for infectious diseases and cancer.
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Immuno-oncology

Defence Therapeutics engineers Accum-mRNA cancer vaccine

April 12, 2023
Defence Therapeutics Inc. says it has successfully established a strategy conjugating mRNA molecules to Accum, the company’s core technology that enables precision delivery of vaccine antigens or antibody-drug conjugates in their intact form to target cells.
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Electron micrograph of red blood cell infected with Plasmodium falciparum surrounded by knobless uninfected blood cells.
Infection

Ocean Biomedical targets parasite protein PfGARP to tackle malaria

March 22, 2023
Ocean Biomedical Inc. has outlined details of its novel approach to treating malaria. Building on...
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3D printed model of a human papillomavirus particle
Immuno-oncology

Virally driven cancers are mRNA vaccines’ first, and next, frontier

March 6, 2023
By Nuala Moran
In a striking demonstration of how the success of mRNA vaccines against COVID-19 has opened up the potential of the technology in cancer, mice that cleared a tumor after a single administration of an mRNA vaccine, also cleared a second tumor without receiving further immunization. This display of potent immunogenicity formed part of a head-to-head study of three different mRNA technology platforms in human papillomavirus (HPV)-16 associated tumors.
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HIV infected cell
HIV/AIDS

Path to a broadly effective HIV vaccine is coming into focus

Feb. 23, 2023
By Anette Breindl
In the larger picture, the fight against HIV has been a triumph of modern medicine. A patient diagnosed with HIV in the 1980s had a remaining life expectancy of 1 to 2 years. In 2023, they can expect to live another half century. But so far, an HIV vaccine has remained elusive. In the newest phase III failure, Janssen Pharmaceutical Cos. of Johnson and Johnson closed down its Mosaico trial more than a year ahead of schedule, following a data and safety monitoring board’s (DSMB) report saying the study was not expected to hit its primary endpoint.
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