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BioWorld - Tuesday, February 3, 2026
Home » Topics » Clinical

Clinical
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Excellent outcomes for Medtronic Evolut TAVR in low-risk bicuspid AVS patients

March 31, 2020
By Annette Boyle
Results of a study presented at the American College of Cardiology's Annual Scientific Session on March 29 demonstrated “excellent” outcomes following transcatheter aortic valve replacement (TAVR) using the Medtronic plc Evolut in low surgical risk patients with bicuspid aortic valve stenosis.
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Cancer cell and DNA

Grail liquid biopsy test broadly detects cancers, particularly aggressive ones, in large study

March 31, 2020
By Stacy Lawrence
Systematic detection of cancer at earlier stages at a population level could remodel how the medical profession approaches cancer treatment, establishing the potential to reduce cancer mortality by almost one-quarter. That’s according to an analysis based on the latest data from Grail Inc.'s Circulating Cell-free Genome Atlas (CCGA) study.
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Akero arrow sights gold, nearing pivot point in NASH?

March 31, 2020
By Randy Osborne
Akero Therapeutics Inc. rolled out stellar non-COVID-19 (for a change) clinical news with long-acting fibroblast growth factor 21 (FGF21) analogue AKR-001 in biopsy-confirmed nonalcoholic steatohepatitis (NASH), but even in liver disease the pandemic became part of the discussion.
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Renal denervation significantly reduces untreated hypertension

March 30, 2020
By Annette Boyle
Results of the pivotal Spyral-HTN OFF MED study presented at the American College of Cardiology's Annual Scientific Session on March 29 demonstrated significant reduction in blood pressure three months after renal denervation (RDN) in patients with unmedicated hypertension.
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Fractyl offers mechanism of action results, as it aims for intestinal resurfacing U.S. pivotal trial in 2020

March 30, 2020
By Stacy Lawrence
Fractyl Laboratories Inc. has released data from a mixed meal tolerance study that shows its procedure for resurfacing the duodenal mucosa improves fasting blood glucose and reduces liver fat.
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Tuberculosis

South Korea’s Qurient posts phase II success with telacebec in drug-resistant TB

March 27, 2020
By David Ho
HONG KONG – Phase II data of South Korea-based Qurient Co. Ltd.’s novel antibiotic candidate may offer hope that the first universal regimen to treat tuberculosis (TB) regardless of drug resistance status has been found.
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Ovarian cancer illustration

Ovarian fever pumps VBL shares, positive peek at phase III cancer gene therapy

March 26, 2020
By Randy Osborne
During the conference call on earnings in March, CEO Dror Harats told investors that “the most important thing” about VBL Therapeutics Ltd.’s then-upcoming analysis of interim phase III data with gene therapy VB-111 (ofranergene obadenovec) is that it was “designed in a way that will enable us to tell the market if we are at least as good as what we've seen” in the phase II experiment.
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Oncopeptides on track for Q2 NDA for melflufen in myeloma

March 26, 2020
By Cormac Sheridan
Oncopeptides AB remains on track for an NDA filing in the second quarter for its peptide-drug conjugate, melflufen, in relapsed refractory multiple myeloma (RRMM).
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Actemra product packaging

Genentech moves Actemra into phase III COVID-19 trial

March 24, 2020
By Cormac Sheridan
DUBLIN – The Genentech arm of Roche Holding AG plans to move its interleukin-6 inhibitor, Actemra, into a global phase III trial in patients with severe pneumonia associated with COVID-19 infection.
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Testing, testing

First repurposing trial for COVID-19 falls flat

March 24, 2020
By Anette Breindl
The first attempt at using existing drugs to treat patients infected with SARS-CoV-2 has yielded disappointing results.
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