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BioWorld - Sunday, January 18, 2026
Home » Topics » Clinical

Clinical
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Sputnik V vaccine
Experts warn protocols not being followed

Sputnik V: Secrecy around phase III trials in Venezuela

Oct. 20, 2020
By Sergio Held
CAJICA, Colombia – The Russian vaccine candidate Sputnik V, developed by Moscow’s Gamaleya National Research Institute of Epidemiology and Microbiology to prevent the SARS-CoV-2 virus that causes COVID-19, is undergoing phase III trials in Venezuela under complete secrecy.
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In the clinic for Oct. 20, 2020

Oct. 20, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Abpro, Aclaris, Appili, Aptinyx, Bone, Cardiff, Cincor, Cytodyn Evofem, Jazz, Keros, Merck, Neuclone, Neuraptive, Noxxon, Ono, Rafael, TFF, Treadwell, Valneva.
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Product image
TCT Connect 2020

Inari device blasts through pulmonary embolism study endpoints

Oct. 19, 2020
By Annette Boyle
Inari Medical Inc.'s Flowtriever device appears to offer a safer and more effective option for pulmonary embolisms than current treatment with thrombolytics or open embolectomy, according to prospective study presented at the TCT Connect 2020 conference.
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Illustration of vascular system in the legs
TCT Connect 2020

Medtronic reports 9-month data from In.Pact BTK feasibility study

Oct. 19, 2020
By Meg Bryant
Medtronic plc reported promising results from a feasibility study of its In.Pact 0.014 drug-coated balloon (DCB) in critical limb ischemia (ICL) patients with chronic total occlusion (CTO) in the infrapopliteal arteries.
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Skin exam

Closing in on potential tralokinumab approval, Leo posts supportive data

Oct. 19, 2020
By Michael Fitzhugh
New articles highlighting phase III data on the IL-13 inhibitor tralokinumab from Leo Pharma A/S have shown that combining it with topical corticosteroids as needed was effective and well-tolerated in patients with moderate to severe atopic dermatitis.
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Nectin-4 case built for two? Bicycle puts pedal to the mettle

Oct. 19, 2020
By Randy Osborne
Cambridge, U.K.-based Bicycle Therapeutics plc’s phase I dosing about a month ago of its first patient with nectin-4-targeting BT-8009 put the company on the road to hoped-for success by pursuing the same mechanism of action as Padcev (enfortumab vedotin-ejfv), the antibody-drug conjugate (ADC) from Astellas Pharma Inc. and Seagen Inc.
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In the clinic for Oct. 19, 2020

Oct. 19, 2020
Clinical updates, including trial initiations, enrollment status and data readouts and publications: Apellis, Aptose, Intrabio, Leo, Merck & Co., Midatech, Sobi, Ultimovacs, Velosbio.
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Digital 3d heart model showing FFR values along coronary arteries
TCT Connect 2020

FFR processing fails to blunt costs in U.K. study of patients with stable angina

Oct. 16, 2020
By Mark McCarty
Fractional flow reserve (FFR) processing of computed tomography (CT) images has gained a substantial body of momentum over the past few years, but a recent study posed the question of whether it can save health care systems from excess spending for stable angina.
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Illustration of calcified artery, heart
TCT Connect 2020

Positive results seen with Shockwave IVL in pivotal IDE study

Oct. 16, 2020
By Liz Hollis
Shockwave Medical Inc., which is focused on intravascular lithotripsy (IVL) to treat severely calcified cardiovascular disease, saw its stock value rise Friday (NASDAQ:SWAV), eventually closing at $78.22, up $3.47, or 4.64%, following the presentation of positive results from the Disrupt CAD III trial.
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Product image
TCT Connect 2020

Clinicians not ready to throw dirt on Acurate Neo despite clinical trial failure

Oct. 16, 2020
By Mark McCarty
The history of TAVR devices is evolutionary as much as it is revolutionary, or that is at least the take-away from an Oct. 15 virtual session comparing the Acurate Neo device by Boston Scientific Corp., of Marlborough, Mass., with the Corevalve Evolut R by Dublin-based Medtronic plc.
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