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BioWorld - Saturday, December 27, 2025
Home » Topics » Disease categories and therapies » Cardiovascular

Cardiovascular
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J-J-Medtech-logo

J&J rebrands med-tech subsidiaries

Sep. 10, 2024
By Annette Boyle
Johnson & Johnson subsumed five of its medical technology business under the Johnson & Johnson Medtech name. Ethicon, Depuy Synthes, Biosense Webster, Abiomed and Cerenovus no longer exist as independent entities, but J&J announced no changes in the product lineup.
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Brightflow device

Brightflow raises €16.5M for right ventricular implantable pump

Sep. 10, 2024
By Shani Alexander
Brightflow SAS raised €16.5 million (US$18 million) in a series A financing round that will go towards developing its right ventricular mechanical circulatory support system. The company is working towards bringing the first long-term fully percutaneous implantable pump for right-sided heart failure to the market, Sophie Humbert, CEO at Brightflow, told BioWorld.
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Inflammatory

Discovery of AZD-4144, a potent, direct and selective NLPR3 inflammasome inhibitor

Sep. 10, 2024
Astrazeneca plc recently provided details on the discovery of the potent, direct and selective NLPR3 inflammasome inhibitor AZD-4144 for the treatment of inflammatory diseases.
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Epigenetics concept art.
Cardiovascular

PCSK9-targeted epigenetic editor therapy shows durable efficacy in mouse and NHP models

Sep. 10, 2024
Researchers from Chroma Medicine Inc. presented preclinical data for the novel PCSK9-targeted epigenetic editor (PCSK9-EE) being developed as cardiovascular therapy for the reduction of low-density lipoprotein cholesterol.
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Edwards-SAPIEN3-12-6.png

Edwards’ Sapien TAVR devices superior to SAVR in women

Sep. 6, 2024
By Annette Boyle
In the first study to compare transcatheter aortic valve replacement or implantation to surgical aortic valve replacement exclusively in women, Edwards Lifescience Corp.’s Sapien 3 and Sapien 3 Ultra valves provided better outcomes.
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Ribbons of digital data
APACMed Forum 2024

APAC seen as opportunity zone to change health care

Sep. 6, 2024
By Tamra Sami
Asia Pacific is the fastest growing region for health care spending, and by 2030 APAC will account for more than 20% of global health care spending, Tom Lawry, managing director of Second Century Tech told the APACMed Forum 2024 conference held in Singapore, Sept 5-6.
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AI-generated illustration of heart and metabolic impact

Angiodynamics receives CE mark for Auryon atherectomy system

Sep. 6, 2024
By Shani Alexander
Angiodynamics Inc. received CE mark approval for its Auryon atherectomy system which treats peripheral artery disease, including critical limb ischemia and in-stent restenosis. The regulatory clearance expands the company’s global reach as it sees increasing revenues from sales of the device.
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Illustration of heart and lung vasculature in pulmonary hypertension vs. normal
Cardiovascular

Effect of COR-1389 on cardiopulmonary function in pulmonary hypertension associated with right heart failure

Sep. 6, 2024
Researchers from Corteria Pharmaceuticals SAS and Université Paris-Saclay recently presented the preclinical results on a long-acting corticotropin-releasing factor CRF2 receptor agonist, COR-1389.
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Glenmark settles US civil price-fixing allegations

Sep. 5, 2024
Glenmark Pharmaceuticals Inc. USA agreed Sept. 4 to pay $25 million, based on its ability to pay, to resolve the Department of Justice’s civil allegations that it conspired to fix the U.S. price of pravastatin, a generic drug used to treat high cholesterol.
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3D illustration of heart cross section

ESC-ape velocity? Cytokinetics revs HCM case with aficamten

Sep. 5, 2024
By Randy Osborne
Cytokinetics Inc. CEO Robert Blum said his firm chalked “a watershed moment” during last weekend’s congress of European Society of Cardiology (ESC) in London, where further mid- and late-stage data were disclosed with the heart drug aficamten, a myosin inhibitor. South San Francisco-based Cytokinetics rolled out six presentations, including two late breakers, with four concurrent publications in medical journals.
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