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BioWorld - Monday, February 2, 2026
Home » Topics » Disease categories and therapies » Endocrine/metabolic

Endocrine/metabolic
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Hengrui/Kailera obesity asset delivers solid weight loss in phase III

July 22, 2025
By Karen Carey
No Comments
A glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor dual agonist developed by Jiangsu Hengrui Pharmaceuticals Co. Ltd. and licensed by Kailera Therapeutics Inc. has shown a mean weight loss of 19.2% at the 6-mg dose with no plateau over 48 weeks in a phase III trial conducted in China.
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Single strand RNA
Newco news

In ongoing mRNA evolution, SML Biopharm sights new cancer vaccines

July 22, 2025
By Marian (YoonJee) Chu
No Comments
SML Biopharm Co. Ltd. is harnessing mRNA technology to develop novel immunotherapy-based cancer vaccines, including two candidates for cervical and head and neck cancers caused by human papillomavirus (HPV) infection.
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Blue injector pens

Biocon wins first FDA interchangeable label of Novolog biosimilar

July 22, 2025
By Marian (YoonJee) Chu
No Comments
The U.S. FDA on July 15 cleared Biocon Biologics Ltd.’s Kirsty (insulin aspart-xjhz) as the first and only interchangeable biosimilar product referencing Novo Nordisk A/S’ Novolog (insulin aspart), a rapid-acting diabetes medication.
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Single strand RNA
Newco news

In ongoing mRNA evolution, SML Biopharm sights new cancer vaccines

July 21, 2025
By Marian (YoonJee) Chu
No Comments
SML Biopharm Co. Ltd. is harnessing mRNA technology to develop novel immunotherapy-based cancer vaccines, including two candidates for cervical and head and neck cancers caused by human papillomavirus (HPV) infection.
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Endocrine/metabolic

Orexin OX2 receptor agonists described in Idorsia Pharmaceuticals patent

July 21, 2025
Idorsia Pharmaceuticals Ltd. has patented macrocyclic compounds acting as orexin OX2 receptor agonists reported to be useful for the treatment of obesity, pain, fatigue, inflammation, cognitive, sleep, eating and mood disorders.
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Illustration of antibodies attacking the thyroid
Endocrine/metabolic

Crinetics’ TSHR antagonist demonstrates efficacy in thyroid autoimmune disorders

July 21, 2025
No Comments
Graves disease (GD)-associated hyperthyroidism is an autoimmune disorder characterized by the presence of autoantibodies that stimulate the thyroid-stimulating hormone receptor (TSHR), leading to excessive production of thyroid hormones.
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Blue injector pens

Biocon wins first FDA interchangeable label of Novolog biosimilar

July 18, 2025
By Marian (YoonJee) Chu
No Comments
The U.S. FDA on July 15 cleared Biocon Biologics Ltd.’s Kirsty (insulin aspart-xjhz) as the first and only interchangeable biosimilar product referencing Novo Nordisk A/S’ Novolog (insulin aspart), a rapid-acting diabetes medication.
Read More
Endocrine/metabolic

Gasherbrum Bio reports new GLP-1R agonists for diabetes

July 18, 2025
Gasherbrum Bio Inc. has patented new heterocyclic glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of type 2 diabetes, among others.
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Woman and molecular overlay
Endocrine/metabolic

Research shows d3-T has testosterone benefits without estradiol conversion

July 18, 2025
No Comments
In drug development, replacing hydrogen atoms with deuterium may help improve the pharmacokinetic profile without altering pharmacodynamic activity.
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Endocrine/metabolic

VDAC1 inhibitors reported in Abarceo patent

July 17, 2025
Abarceo AB has developed new voltage-dependent anion-selective channel protein 1 (VDAC1) inhibitors reported to be useful for the treatment of diabetes type 1 and 2.
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