Preserving beta-cell mass and expansion is a key point in diabetes. Prolonged hyperglycemia may lead to glucose toxicity, which impairs insulin production and secretion, promoting a cycle with increasing glucose concentrations that promote a decline of beta-cell function and eventually their death.
Preterm birth is the leading cause of death in children under 5 and those who survive commonly suffer from life-long deleterious health impairments. Preterm labor (PTL) is defined as sustained contractions prior to 37 weeks of gestation, which occurs in about 10% of all pregnancies in the U.S. The mechanisms that initiate PTL are still not well understood; researchers aimed for the identification of molecular targets for PTL.
Earth Chemical has patented lipoprotein lipase (LPL) activators reported to be useful for the treatment of hypertriglyceridemia. An exemplified compound rescued LPL from N-terminal GST-tagged angiopoietin-like 4 (ANGPTL4)-induced inactivation (EC50 = 1.01 mcM) in fluorescence-based assays.
Stinging nettle leaf has been used in traditional treatments for conditions such as lower urinary tract symptoms, possibly through a smooth muscle relaxant effect. Monash University scientists have investigated the mechanism in studies in vitro and in vivo.
During pregnancy, the female body experiments multiple physiological changes that require modulation of the neuroendocrine system, mainly being contributed by the hormone prolactin and its regulation by the hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons.