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BioWorld - Saturday, September 23, 2023
Home » Topics » Disease categories and therapies » Endocrine/Metabolic

Endocrine/Metabolic
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Test tubes, dropper and capsules
Endocrine/Metabolic

Krystal Biotech’s KB-408 awarded US orphan drug designation for AATD

Sep. 5, 2023
No Comments
The FDA has awarded orphan drug designation to Krystal Biotech Inc.’s KB-408 for the treatment of α1-antitrypsin deficiency (AATD).
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Endocrine/Metabolic

US researchers present new RXFP2 agonists

Sep. 4, 2023
No Comments
Researchers from Florida International University and U.S. Department of Health and Human Services have divulged fused diazepines acting as relaxin receptor 2 (RXFP2; LGR8) agonists.
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Genexine drug meets phase III endpoint in pediatric growth hormone deficiency

Sep. 1, 2023
By Tamra Sami
No Comments
Genexine Co. Ltd.’s recombinant human growth hormone eftansomatropin alfa (GX-H9/TJ-101) met the primary endpoint in a phase III pediatric study conducted in China in children with growth hormone deficiency, and the company plans to file a BLA in 2024 in China on the data.
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3D heart in chest
Cardiovascular

Activity of novel GalNAc-siRNA option in models supports advancement into the clinic

Sep. 1, 2023
No Comments
Apolipoprotein C3 (APOC3) is one of the main regulators of triglyceride metabolism. Hypertriglyceridemia (HTG) is a major risk factor for cardiovascular disease and there is evidence that loss-of-function mutations in APOC3 correlate with decreased plasma triglyceride levels and subsequent reduced cardiometabolic dysfunction.
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Endocrine/Metabolic

Medimmune divulges new dual GCGR/GLP-1R agonists

Aug. 30, 2023
No Comments
Medimmune Ltd. has prepared and tested lipidated peptide analogues with improved stability acting as dual agonists of glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R). They are reported to be useful for the treatment of obesity, nonalcoholic steatohepatitis (NASH) and type 2 diabetes.
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Vascular system
Cardiovascular

Eli Lilly presents the preclinical profile of LY-3473329

Aug. 30, 2023
No Comments
Human lipoprotein(a) (Lp(a)) is a lipoprotein complex composed of a low-density lipoprotein (LDL) particle and a large highly polymorphic glycoprotein named apolipoprotein (a) (apo(a)). There is evidence that Lp(a) is linked to cardiovascular disorder risk.
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Test tubes, capsules, dropper
Drug Design, Drug Delivery & Technologies

CCM Biosciences outlines preclinical pipeline on launch

Aug. 30, 2023
No Comments
CCM Biosciences Inc. has launched with a focus on discovering and developing novel drugs, including small molecules, gene therapies, biologics and nanomedicines, and companion diagnostic tests.
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Colorful illustration of the heart
Endocrine/Metabolic

AT-02, a humanized IgG1-peptide fusion reagent that potently binds cardiac amyloid

Aug. 30, 2023
No Comments
At the recent ESC Congress, researchers from University of Tennessee and Attralus Inc. presented preclinical data on the novel pan-amyloid-binding peptide fusion immunoglobulin AT-02, which is being developed for the treatment of amyloidosis.
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Hear with tape measure
Endocrine/Metabolic

A novel NLRP3 inhibitor reverses the cardiometabolic impact of obesity in models

Aug. 24, 2023
No Comments
Obesity is known to be associated with metabolic and cardiovascular disorders such as insulin resistance, type 2 diabetes, hypertension, or heart failure, all presenting a chronic low-grade inflammatory component. The activation of the NLRP3 inflammasome pathway appears to be linked to the development of cardio-metabolic diseases.
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Illustration of pancreas, close up of islet
Endocrine/Metabolic

Abata Therapeutics selects ABA-201 Treg cell therapy as development candidate for type 1 diabetes

Aug. 24, 2023
No Comments
Abata Therapeutics Inc. has announced its second development candidate, ABA-201, which has the potential to be a disease-modifying Treg cell therapy for patients with type 1 diabetes who have remaining β cell function. Abata expects to begin clinical studies in 2025.
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