A protein called apoptosis inhibitor 5 (API-5) protects intestinal Paneth cells, which are disrupted in Crohn’s disease, and could lead to a new treatment for the inflammatory bowel disease. Writing in the Oct. 5, 2022, online issue of Nature, Ken Cadwell, a professor of microbiology at New York University Grossman School of Medicine, and colleagues described testing the protein in a mouse model and in gut organoids with good results. Crohn’s disease is one of two key autoimmune diseases that affect the gut, the second of which is ulcerative colitis. Combined, inflammatory bowel diseases affect around 3 million people in the U.S. While there is currently no cure for these conditions, there are monoclonal antibody therapies available.
Endpoint Health Inc. has announced a new precision immunology program targeting inflammation mediated by tissue factor (TF)-dependent intracellular signaling.
Terns Pharmaceuticals Inc. has patented thyroid hormone receptor β (THRβ) agonists reported to be useful for the treatment of nonalcoholic steatohepatitis.
Convalife (Shanghai) Health Technology Co. Ltd. has presented new thyroid hormone receptor α (TR-α) and (TR-β) agonists reported to be useful for the treatment of nonalcoholic fatty liver disease, obesity, liver fibrosis, type 2 diabetes and hypercholesterolemia.
Aqualung Therapeutics Corp. has been awarded two 3-year National Institutes of Health (NIH) Fast Track awards to support development of ALT-100 (enamptcumab), a humanized monoclonal antibody therapy for the chronic indications of pulmonary arterial hypertension (PAH) and inflammatory bowel disease (IBD).
Medshine Discovery Inc. has patented new sulfinylpyridine-containing nonreceptor tyrosine-protein kinase TYK2 inhibitors expected to be useful for the treatment of Crohn's disease, systemic lupus erythematosus, psoriasis, psoriatic arthritis and ulcerative colitis.
Concentric Analgesics Inc. has discovered transient receptor potential cation channel subfamily M member 8 (TRPM8) agonists reported to be useful for the treatment of oropharyngeal dysphagia.
Qilu Regor Therapeutics Inc. has identified (hetero)arylamino-cyclohexyl-sulfonyl derivatives acting as C-C chemokine receptor type 6 (CCR6) antagonists reported to be useful for the treatment of inflammatory bowel disease, Crohn's disease and ulcerative colitis.
China's National Medical Products Administration (NMPA) has cleared CSPC Pharmaceutical Group Limited to conduct clinical trials of TG-103 injection for the treatment of Alzheimer's disease and for the treatment of nonalcoholic steatohepatitis (NASH).
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