Pseudomonas aeruginosa uses the quorum sensing (QS) system to regulate virulence factors expression and biofilm development. Researchers from Jinan University reported on novel inhibitors of P. aeruginosa transcriptional activator proteins LasR and LasB.

Human African trypanosomiasis (HAT) is a neglected tropical disease caused by the vector-borne parasites Trypanosoma brucei gambiens or Trypanosoma brucei rhodesiense. Despite the recent approval of fexinidazole, novel antitrypanosomal agents are needed to attain its targeted eradication by 2030.

Sail Biomedicines Inc. has received two grants from the Bill & Melinda Gates Foundation to advance the company's Endless RNA (eRNA) platform to develop secreted monoclonal antibodies and vaccines for malaria.

Researchers have identified a new class of antibiotics that works by blocking the transportation of lipopolysaccharide (LPS) to the outer membrane of the gram-negative bacterium Acinetobacter baumannii. The most advanced member of the class, zosurabalpin (RG-6006, Roche AG), was effective against multiple A. baumannii strains, including carbapenem-resistant and multidrug-resistant strains.

Ubidx Inc. has designed a diagnostic system comprised of a fluidic single-use disposable and a base. While the fluidic single-use disposable or cartridge is generally described as being suitable for testing a single sample, the base or hub may be used numerous times to perform numerous tests using numerous fluidic single-use disposables or cartridges.

Acinetobacter baumannii, a gram-negative opportunistic bacteria causing nosocomial bloodstream, urinary tract and airway infections, poses a high disease burden worldwide, particularly in Sub-Saharan Africa. Moreover, A. baumannii is a multidrug resistance (MDR) critical priority pathogen that could contribute up to 10 million deaths annually by 2050. Therefore, novel antibiotic approaches to treat MDR A. baumannii constitute a critical medical need.

Researchers from Banasthali University and Central Drug Research Institute (CDRI) have reported the discovery of novel antimalaria candidates.

It is not the first malaria vaccine, but R21, recommended for use by the World Health Organization in October, is the first that can be manufactured at modest cost and the sort of scale needed for widespread prevention of the killer disease in Africa.