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BioWorld - Sunday, June 14, 2026
Home » Topics » Disease categories and therapies » Musculoskeletal

Musculoskeletal
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Endocrine/metabolic

Japan Tobacco divulges PDE7A inhibitor for osteoporosis prevention

Jan. 28, 2025
Due to the widespread presence of PDE7 in various tissues, the development of PDE7 inhibitors has been limited by potential adverse side effects.
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Veru weight loss study hits primary endpoint, stock drops

Jan. 27, 2025
By Lee Landenberger
Positive data for Veru Inc.’s enobosarm lend more weight to the potential progress of the company’s body-mass preservation program in patients taking Wegovy (semaglutide). The side effect of lean mass loss has dogged those taking GLP-1s. The study results didn’t support the company’s stock on the day of the data release as it had the previous four weeks.
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Musculoskeletal

Xi’an Xintong Medicine Research divulges new JAK3 inhibitors

Jan. 27, 2025
Xi’an Xintong Medicine Research Co. Ltd. has synthesized tyrosine-protein kinase JAK3 inhibitors reported to be useful for the treatment of rheumatoid arthritis, alopecia areata, vitiligo, asthma, chronic obstructive pulmonary disease, cancer and inflammatory bowel disease.
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Blue and pink illustration of a see-through human head showing brain and glowing endocrine glands and flowing energy lines
Endocrine/metabolic

Study links muscle hormone to reproductive function

Jan. 22, 2025
By Mar de Miguel
A paracrine hormone of skeletal muscle acts as an endocrine signal for the synthesis of a sex hormone. Scientists at McGill University have observed in mice how myostatin, which inhibits the development of muscle mass to control its growth, also stimulated the production of the pituitary follicle-stimulating hormone (FSH), modulating ovarian function. The hypothalamus-pituitary-gonadal axis could include an additional element through a yet unknown role in muscles.
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Omniabio building

Medipost grows US, Canada base; plans US phase III of Cartistem

Jan. 21, 2025
By Marian (YoonJee) Chu
As more Asia biotechs turn to regenerative medicine to address disorders without a cure, Medipost Inc. is continuing global expansion with Cartistem, its allogeneic human umbilical cord blood-derived mesenchymal stem cell product that gained clearance in South Korea in 2012 to treat knee osteoarthritis.
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Hands holding test tubes at laptop

Mapping GLP-1RA effects turns up benefits, risks, ‘master lessons in biology’

Jan. 21, 2025
By Anette Breindl
The largest analysis to date of patients taking GLP-1 receptor agonists (GLP-1RAs) has investigated their effects on nearly 175 diseases, and found that compared to three other classes of diabetes medications, individuals with a prescription for GLP-1RAs had a reduced risk of 42 diseases, and an increased risk of 19.
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Hands holding test tubes at laptop
Endocrine/metabolic

Mapping GLP-1RA effects turns up benefits, risks, ‘master lessons in biology’

Jan. 20, 2025
By Anette Breindl
The largest analysis to date of patients taking GLP-1 receptor agonists (GLP-1RAs) has investigated their effects on nearly 175 diseases, and found that compared to three other classes of diabetes medications, individuals with a prescription for GLP-1RAs had a reduced risk of 42 diseases, and an increased risk of 19. The findings, which were published Jan. 20, 2025, in Nature Medicine, provide a comprehensive overview of GLP-1RAs’ effects.
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Omniabio building

Medipost grows US, Canada base; plans US phase III of Cartistem

Jan. 15, 2025
By Marian (YoonJee) Chu
As more Asia biotechs turn to regenerative medicine to address disorders without a cure, Medipost Inc. is continuing global expansion with Cartistem, its allogeneic human umbilical cord blood-derived mesenchymal stem cell product that gained clearance in South Korea in 2012 to treat knee osteoarthritis.
Read More
Medical art concept for radicular leg pain or sciatic nerve pain

Seikagaku’s Ferring-partnered condoliase for pain wins at adcom

Jan. 14, 2025
By Randy Osborne
Data from two out of three positive studies faced the U.S. FDA’s Anesthetic and Analgesic Drug Products Advisory Committee as members examined the package submitted by Seikagaku Corp., of Tokyo, for SI-6603 (condoliase), a chemonucleolytic drug for radicular leg pain associated with lumbar disc hernia.
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Illustration of man holding magnifying glass to human body model showing muscle anatomy
Neurology/psychiatric

Targeted exon-skipping strategy restores dysferlin function in muscular dystrophy model

Jan. 14, 2025
Recent work proposes a promising therapeutic approach for dysferlinopathies.
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