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Home » Topics » Disease categories and therapies » Obesity

Obesity
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Lei Qian, clinical vice president, Innovent

Innovent raises HKD$4.3B to advance R&D pipeline, global expansion

July 1, 2025
By Tamra Sami
No Comments
Innovent Biologics Inc. announced a HKD$4.3 billion (US$547 million) placement on the Hong Kong Stock Exchange to advance its R&D projects and to fund its global expansion.
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UK launches pharmacogenomics project targeting GLP-1s

June 30, 2025
By Nuala Moran
No Comments
The increased use of GLP-1 receptor agonists has led on to an increase in reports of acute pancreatitis in people taking these weight loss drugs in the U.K. That has prompted the launch of a pharmacogenomics project to investigate if there are any genetic links underlying the occurrence of this adverse event.
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Lei Qian, clinical vice president, Innovent

Innovent raises HKD$4.3B to advance R&D pipeline, global expansion

June 26, 2025
By Tamra Sami
No Comments
Innovent Biologics Inc. announced a HKD$4.3 billion (US$547 million) placement on the Hong Kong Stock Exchange to advance its R&D projects and to fund its global expansion.
Read More
3-30-fractyl-revita.png

Fractyl pursues dual track to cure T2 diabetes

June 23, 2025
By Annette Boyle
At the American Diabetes Association 85th Scientific Sessions in Chicago June 20-23, Fractyl Health Inc. presented results from two studies evaluating very different approaches to treating – and possibly curing – type 2 diabetes.
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Pharmalytix insulin test
Patents

Pharmalytix files patent for insulin degradation home test

June 13, 2025
By Simon Kerton
In what represents the company’s first filing, the co-founders of Pharmalytix Inc., Sierra Houang and Lee Grady, describe their creation of a simple, quick, low-cost at home lateral flow test for determining insulin quality.
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AI-generated illustration of heart and metabolic impact

Deep Apple signs big Novo deal for cardiometabolic small molecules

June 11, 2025
By Lee Landenberger
No Comments
Deep Apple Therapeutics Inc. could bring in as much as $812 million in a new collaboration and license deal with Novo Nordisk A/S. The total includes an unspecified up-front payment, research costs and milestones. The two plan to develop and commercialize oral small molecules for non-incretin G-protein coupled receptor targets for treating cardiometabolic diseases, including obesity, a core specialty for Novo Nordisk.
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Dexcom G7 CGM

Diabetes partnerships abound ahead of ADA

June 10, 2025
By Annette Boyle
With the American Diabetes Association annual meeting a week away, four major diabetes tech companies queued up new partnerships for their devices.
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Metsera’s long-acting amylin analogue delivers in phase I

June 9, 2025
By Jennifer Boggs
No Comments
One of the big questions going into the phase I readout for Metsera Inc.’s amylin analogue, MET-233i, was whether findings would support once-monthly dosing for the potential obesity candidate. They did. Results also indicated solid and dose-dependent weight loss activity, and Metsera was able to identify well-tolerated starting doses for subsequent studies, said Steve Marso, chief medical officer. “So we exceeded expectations on all three scientific objectives.”
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Ozempic pen and packaging

EMA warns Ozempic linked to ‘very rare’ side effect

June 6, 2025
By Nuala Moran
No Comments
The EMA’s safety committee has issued a warning that the GLP-1 receptor agonist Ozempic (semaglutide, Novo Nordisk A/S) can cause an acute eye condition in which the optic nerve is damaged by a sudden loss of blood supply. After reviewing several large epidemiological studies, clinical trial and in-market data, EMA’s Pharmacovigilance Risk Assessment Committee has concluded non-anterior ischemic optic neuropathy is a “very rare” side effect of Ozempic, that “may affect up to one in 10,000 people taking semaglutide.
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GLP-1 receptor, inactive form vs. active complex with an agonist (semaglutide) and G-proteins

Fractyl, Bariendo developing off-ramp for post-GLP-1 maintenance

June 4, 2025
By Annette Boyle
Far from eliminating the need for weight-loss procedures, glucagon-like peptide-1 receptor agonists could drive more people to seek them out. At least that’s what Fractyl Health Inc. and Bariendo Inc. hope, and they have strong evidence to support their case with a recent meta-analysis showing that individuals discontinuing the popular weight loss medications regain all their weight and more within two years.
Read More
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