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Home » Topics » Disease categories and therapies » Obesity

Obesity
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Blue injector pens

No longer a two-horse race: Obesity drug competition expands

June 27, 2024
By Brian Orelli
The obesity market is hot with Novo Nordisk A/S generating $6.3 billion in sales from its semaglutide-containing drugs, Ozempic, Saxenda, Rybelsus and Wegovy, in the first quarter of 2024 and Eli Lilly and Co. bringing in $2.3 billion for its tirzepatide-containing drugs, Zepbound and Mounjaro, in the same quarter. It appears unlikely the market will be a two-horse race for much longer though.
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Liver disease

Innovent’s mazdutide reduces liver fat content in obese patients

June 25, 2024
By Tamra Sami
Innovent Biologics Inc.’s glucagon-like peptide-1 receptor and glucagon receptor dual agonist, mazdutide, saw 80% reduction in liver fat content in patients with more than 10% liver fat content in the phase III Glory-1 obesity trial.
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Rahul Dhanda, president and CEO, Syntis Bio
Newco news

Syntis Bio launches for oral obesity, rare disease drugs

June 12, 2024
By Karen Carey
Focused on oral therapies for obesity, diabetes and rare diseases, Boston-based Syntis Bio Inc., which raised $15.5 million through seed funding last year, emerged from stealth to advance its synthetic tissue-lining technology and a pipeline of candidates.
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Rahul Dhanda, president and CEO, Syntis Bio
Newco news

Syntis Bio launches for oral obesity, rare disease drugs

June 11, 2024
By Karen Carey
Focused on oral therapies for obesity, diabetes and rare diseases, Boston-based Syntis Bio Inc., which raised $15.5 million through seed funding last year, emerged from stealth to advance its synthetic tissue-lining technology and a pipeline of candidates.
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Eye and financial charts

Skye writing off glaucoma post-phase II, airs obesity plan

June 10, 2024
By Randy Osborne
After the phase IIa failure at lowering intraocular pressure to a statistically significant degree with SBI-100, Skye Bioscience Inc. is dropping work with the ophthalmic emulsion, meant to treat primary open-angle glaucoma or ocular hypertension. Resources are turning to the firm’s metabolic program, which includes nimacimab, targeting the cannabinoid 1 receptor, due to start a phase II trial in obesity during the third quarter of this year.
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Antibodies
Endocrine/metabolic

Sixpeaks launches to advance its dual activin IIA/B antibody

June 5, 2024
By Nuala Moran
Obesity specialist Sixpeaks Bio AG emerged from stealth with $110 million in funding and an option to be acquired by Astrazeneca plc within the next two years, subject to filing an IND for the lead product. Of the $110 million, $30 million is a series A round, with the balance to come from Astrazeneca, which will provide nondilutive finance of up to $80 million.
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Structure regains ground on oral GLP-1 phase IIa obesity data

June 3, 2024
By Jennifer Boggs
Shares of Structure Therapeutics Inc. (NASDAQ:GPCR) were trading up more than 54%, gaining $18.54 to close June 3 at $52.74, on the back of data for GSBR-1290, an oral, GLP-1 receptor agonist it hopes to position in the highly competitive obesity market. The latest readout sees the company regaining ground lost late in 2023 when earlier phase IIa data prompted unflattering comparisons to more advanced oral GLP-1 candidates.
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Antibodies
Newco news

Sixpeaks launches to advance its dual activin IIA/B antibody

May 31, 2024
By Nuala Moran
Obesity specialist Sixpeaks Bio AG emerged from stealth with $110 million in funding and an option to be acquired by Astrazeneca plc within the next two years, subject to filing an IND for the lead product.
Read More

Lilly’s Qwint claim: Deed done weekly insulin phase III

May 16, 2024
By Randy Osborne
As a meeting looms of the U.S. FDA’s Endocrinologic and Metabolic Drugs Advisory Committee to evaluate a similar product from Novo Nordisk A/S, Eli Lilly and Co. made public positive top-line phase III data with its once-weekly insulin, efsitora alfa, in adults with type 2 diabetes using insulin for the first time and in those who require multiple daily injections.
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Pills, bottle, scale and-measuring tape

Bio Korea 2024: What’s next after GLP-1 in obesity, diabetes?

May 14, 2024
By Marian (YoonJee) Chu
Homerun success of Novo Nordisk A/S’ semaglutide, which recently became the U.S.’s biggest blockbuster drug, is serving as an “inflection point” for obesity therapeutics and fueling the drive for new and improved therapies, speakers said at Bio Korea 2024 on May 8.
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