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BioWorld - Thursday, June 8, 2023
Home » Topics » Drugs » Antibody

Antibody
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Antibodies
Cancer

Albatroz Therapeutics secures funding to develop therapeutic antibodies to treat solid tumors and arthritis

April 26, 2023
No Comments
Albatroz Therapeutics Pte Ltd. has secured $3 million in funding to accelerate the development of therapeutic antibodies against a novel target that degrades the extracellular matrix, a key contributor to cancer and arthritis.
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Colorized transmission electron micrograph of yellow fever virus particles.
Infection

Preclinical treatment neutralizes yellow fever virus

April 5, 2023
No Comments
Two neutralizing monoclonal antibodies isolated from volunteers vaccinated against the yellow fever virus controlled the viremia and prevented severe disease and death in hamsters and primates.
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Antibodies attacking cancer cell
Immuno-oncology

Immunoprecise Antibodies announces collaboration with Xyphos on antibodies against TME target

March 31, 2023
No Comments
Immunoprecise Antibodies Ltd.'s Talem Therapeutics LLC subsidiary has entered into a research collaboration and exclusive option license agreement with Xyphos Biosciences Inc., a wholly owned subsidiary of Astellas Pharma Inc.
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3D concept image of nanoparticle layers
Immuno-oncology

Talem Therapeutics collaborates with Libera Bio to develop novel antibodies for use with MPN delivery

March 16, 2023
No Comments
Talem Therapeutics LLC, an independently...
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Antibodies attacking cancer cell
Immuno-oncology

Eureka Therapeutics licenses antibody targeting mesothelin from NCI

March 15, 2023
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Eureka Therapeutics Inc. has entered into a license agreement with the National Cancer Institute (NCI) to develop and commercialize a novel antibody targeting mesothelin (MSLN) in combination with Eureka's proprietary Artemis T-cell receptor platform.
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Coronavirus spike protein
Infection

Exevir Bio reports on anti-S2 camelid single-domain antibody-based drug XRV-013

March 13, 2023
No Comments
Exevir Bio BV has announced research detailing a novel, highly potent, anti-S2 camelid single-domain antibody, discovered at the VIB-Ugent Center for Medical Biotechnology, and developed as a candidate drug molecule by Exevir as XVR-013.
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Infection

Autoantibodies against chemokines are possible ally against long COVID

March 7, 2023
By Mar de Miguel
No Comments
Autoantibodies are typically not good news. But a group of researchers from Bellinzona, Switzerland, have observed that the presence of autoantibodies against chemokines, a special class of cytokines, is associated with mild disease and less risk of developing long COVID. “Our hypothesis was that antibodies to chemokines, if they existed, would also be associated with a negative outcome of the disease. But, what we found, in fact, was the exact opposite of what we were predicting,” Davide Robbiani, director of the Institute for Research in Biomedicine, told BioWorld.
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Grizzly bear hunting salmon in river
Immune

Function of mysterious ‘grizzly-like’ macrophage gives insights into autoimmunity

March 3, 2023
By Tamra Sami
No Comments
Even its name is a testament to how enigmatic the tingible macrophage has been. Tingible, which means stainable, certainly gives no clues to its functions – but was, at least, one thing that was known about the cells. Now, scientists at the Garvan Institute of Medical Research have tracked the lifecycle and function of tangible macrophages in the lymph nodes, with implications for understanding autoimmune disorders, which are still poorly understood. Published March 2, 2023, in the journal Cell, the study highlights intravital imaging techniques the scientists used to observe how macrophages formed within the lymph nodes and how they behaved in real time.
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Illustration of ovaries and uterus with endometriosis
Endocrine/Metabolic

Long-lasting effects by ‘recycled’ antibodies improve endometriosis lesions in primate study

March 1, 2023
By Subhasree Nag
No Comments
A multi-institutional team of researchers has reported the development of an anti-IL-8 antibody against endometriosis using recycling antibody engineering technology. The study confirmed the role of the inflammatory cytokine IL-8 in the development of inflammation and fibrosis in endometriosis and showed that administration of IL-8 antibodies in primate models improved endometriosis pathology.
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Breaking new ground with knotbodies, Maxion raises $16M

Feb. 15, 2023
By Nuala Moran
No Comments
Maxion Therapeutics Ltd. has raised $16 million in a series A to take forward a new method for drugging G-protein coupled receptors (GPCRs) and ion channels with antibodies. The technology brings together naturally occurring knottin peptides that are derived from sources such as snake venom and which can engage GPCRs and ion channels, with antibodies that deliver them to these notoriously difficult, shape-shifting targets.
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