Modex Therapeutics Inc. has been awarded a contract from the Biomedical Advanced Research and Development Authority (BARDA) to advance a platform and specific candidates designed to address a range of public health threats in viral infectious diseases.
Lyme disease, caused by the bacteria Borrelia burgdorferi and transmitted by Ixodes ticks, is expanding in many countries, posing a significant global health concern. The outer surface protein A (OspA) of B. burgdorferi is currently the most promising target for vaccine development, primarily because of its broad conservation among different bacterial strains that cause the disease. In a recent publication, researchers from the University of Pennsylvania and collaborators proposed using a lipid nanoparticle-encapsulated nucleoside-modified mRNA (mRNA-LNP) platform, similar to that of clinical vaccines against SARS-CoV-2, to develop a vaccine against Lyme disease.
Viruses of the Betacoronavirus genus that bind to angiotensin-converting enzyme 2 (ACE2) are the coronaviruses posing the most significant pandemic risk. Sarbecoviruses of this genus caused the severe acute respiratory syndrome (SARS) epidemic and the SARS-CoV-2 pandemic. Therefore, new vaccines with broader protection from ACE2-binding sarbecoviruses and emerging variants of concern are urgently needed.
The Global Health Innovative Technology (GHIT) Fund has announced new investments in the development of a new prophylactic vaccine against malaria, a new anti-malarial drug, and product development projects against neglected tropical diseases.
Phylex Biosciences Inc. has announced plans to pursue the development of a nanoparticle mRNA vaccine against the Nipah virus. Last year, the company published proof of principle for its second-generation nanoparticle mRNA vaccine against the SARS-CoV-2 delta virus.
Transimmune AG has been awarded a $5 million investment from the Bill & Melinda Gates Strategic Investment Fund that will be used to leverage Transimmune’s physiologically induced dendritic cells (phDCs) to enhance the potency of mRNA vaccines in infectious diseases. The initial focus will be on a therapeutic vaccine for people with HIV.
Spybiotech Ltd. has filed a clinical trial application (CTA) with the U.K. Medicines and Healthcare products Regulatory Agency (MHRA) to evaluate SPYVLP-01, a vaccine targeting human cytomegalovirus (CMV) using its hepatitis B virus-like-particle platform technology.
Evaxion Biotech A/S has announced the initiation of a novel pipeline program, EVX-B3, an artificial intelligence (AI)-designed vaccine candidate against an undisclosed bacterial pathogen. The new vaccine project will be the subject of a co-funded collaboration between Evaxion and an undisclosed partner.
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