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BioWorld - Monday, October 2, 2023
Home » Topics » Newco news

Newco news
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Lungs anatomy
Newco news

Anoat takes aim at alternative chloride channel to treat cystic fibrosis

Aug. 10, 2023
By Caroline Richards
No Comments
With more than 70,000 people living with cystic fibrosis (CF) worldwide, according to the Cystic Fibrosis Foundation, the introduction of CF transmembrane conductance regulator (CFTR) modulator therapies has revolutionized treatment of the disease. However, these drugs are not effective for around 10% of CF patients, driving a significant unmet therapeutic need. One startup hoping to address this is Anoat Therapeutics.
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Dotbio CEO Ignacio Asial with team
Newco news

Dotbio emerges with $5.6M pre-series A to advance multifunctional antibodies

Aug. 9, 2023
By Tamra Sami
No Comments
Emerging from stealth mode, new immuno-oncology company Dotbio Pte. Ltd. closed an oversubscribed $5.6 million pre-series A round to accelerate development of its multifunctional and intracellular antibody therapies.
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Michelle Werner, CEO, Alltrna
Newco news

Alltrna-tive approach in transfer RNA draws $109M series B

Aug. 9, 2023
By Randy Osborne
No Comments
Alltrna Inc. raised $109 million in a series B round to back its work with transfer RNA, with the first targeted indication of stop codon disease: a condition that takes in thousands of rare and common afflictions stemming from nonsense mutations where the amino acid code has been mutated into a “stop” codon, also known as a premature termination codon.
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Palm of hand
Newco news

Connext to kick off phase I/II trial for ‘high-quality, affordable’ Dupuytren’s contracture drug

Aug. 8, 2023
By Marian (YoonJee) Chu
No Comments
South Korean biopharma Connext Co. Ltd. is set on outdoing standard-of-care therapies for Dupuytren’s contracture. The Daegu-headquartered Connext recently secured U.S. FDA IND approval for a phase I/II trial on its recombinant collagenase clostridium histolyticum, called CNT-201, inching closer to its goal of providing an affordable but high-quality therapeutic option for patients with the rare, progressive connective tissue disorder.
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Targets with arrows
Newco news

Nexo emerges with $60M series A, takes aim at ‘elusive’ targets

Aug. 4, 2023
By Jennifer Boggs
No Comments
When looking for a name, the founders of startup Nexo Therapeutics Inc., which recently emerged from stealth mode with a $60 million series A financing and a research collaboration with the University of Texas MD Anderson Cancer Center, sought a moniker that truly captured its approach to drug development.
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Amber Bio co-founders Jacob Borrajo and Basem Al-Shayeb
Newco news

With $26M in funding, RNA editing firm Amber Bio targets diverse mutations

Aug. 4, 2023
By Karen Carey
No Comments
New company Amber Bio emerged on Aug. 3 with $26 million in seed funding that will help advance an RNA-based gene editing platform that leverages Cas-based systems to create safer medicines. Through the company’s platform, a single drug can be used to treat diseases with high allelic diversity. The company plans to develop its own genetic medicines internally, while also licensing out the technology to expand its reach.
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Antibodies attacking cancer cell
Newco news

Solu secures $31M to progress two-pronged small molecule approach

Aug. 2, 2023
By Caroline Richards
No Comments
Precision medicine startup Solu Therapeutics has raised $31 million in an oversubscribed seed round to advance a therapeutic candidate based on technology that identifies cell surface, tumor-associated targets that antibodies alone fail to latch onto. The company was founded by venture capital firm Longwood Fund and has high hopes for its cytotoxicity targeting chimera platform. “[It] has the potential to unlock new tumor-associated antigens and develop molecules that deplete pathogenic immune cells and extend the half-life of small-molecule antagonists and agonists,” CEO and co-founder of Solu, David Donabedian, told BioWorld.
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Tree in the shape of human head losing leaves
Newco news

Viage to advance gut-drug for cognitive impairment to phase II

Aug. 1, 2023
By Marian (YoonJee) Chu
No Comments
Viage Therapeutics Inc. – formerly Digestome Therapeutics Inc. – on July 26 unveiled positive data from its phase I study on DGX-001 for mild cognitive impairment in Alzheimer’s disease (AD) and Parkinson’s (PD). The randomized, double-blind, placebo-controlled study demonstrated changes in brain activity according to quantitative electroencephalography (qEEG) measurements in 68 healthy volunteers dosed with single ascending and multiple ascending doses.
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Real fluorescence microscopic view of human neuroblastoma cells
Newco news

Renaissance launches with neuroblastoma antibody candidate

Aug. 1, 2023
By Nuala Moran
No Comments
Newco Renaissance Pharma Ltd. has been formed to take a new treatment for neuroblastoma developed at St Jude’s Children’s Research Hospital through to market. The product, Hu14.18, has been in-licensed following a phase II trial conducted at the hospital in which patients with newly diagnosed high-risk neuroblastoma had a three-year event-free survival of 73.7% and an overall survival of 86%.
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Seedling growing in cracked pavement
Newco news

Artbio raises $23M to advance lead-based radioligand therapies for prostate cancer

July 28, 2023
By Caroline Richards
No Comments
The radiopharmaceuticals field is gaining traction as companies realize that by harnessing the power of radioactive atoms, they can create targeted and more effective cancer drugs which cause less damage to healthy tissues. As a result, competition for a place as a leading radiopharma firm is high, and the market is estimated to reach $11.5 billion by 2027.
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