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Cancer

Novel selective HPK1 inhibitors for cancer treatment disclosed

March 30, 2023

Hematopoietic progenitor kinase 1 (HPK1) is essential for T-cell function activation, which in...

Neurology/Psychiatric

Sanofi presents selective CSF-1R inhibitor for the treatment of multiple sclerosis

March 30, 2023

The identification and evaluation of the activity of a novel, selective, brain-penetrant macrophage...

Immuno-oncology

Murine model study explores CAR T-cell efficacy and associated toxicity

March 29, 2023

Chimeric antigen receptor (CAR) T-cell therapy is a powerful approach for patients with hematologic malignancies, such as leukemia. Its broad use may be associated with life-threatening toxicities such as neurotoxicity and cytokine release syndrome (CRS).

Neurology/Psychiatric

New murine DMD model resembles the severe phenotype seen in humans

March 29, 2023

The main features of Duchenne muscular dystrophy (DMD) are muscle weakness and...

Substance Use & Poisoning

New opioid receptor modulator has the noncompetitive advantage

March 29, 2023

By Anette Breindl

Researchers at Indiana University Bloomington have developed allosteric modulators of the opioid receptor that were superior to the opioid antidote naloxone at blocking the effects of fentanyl in vitro. They presented their work in a session on “Progress towards more efficacious medicine: Antibiotics and antidotes” at the 2023 spring meeting of the American Chemical Society (ACS).

Inflammatory

Atyr Pharma’s tRNA synthetase candidate ATYR-0101 binds to fibrosis target LTBP-1

March 28, 2023

Researchers from Atyr Pharma Inc. presented findings from the innovative tRNA synthetase platform, highlighting ATYR-0101, a potential therapeutic biologic based on a domain appended to aspartyl-tRNA synthetase (DARS).

Cancer

Wild-type and C481S mutant BTK inhibitor HND-01 shows potent antitumoral activity

March 28, 2023

Hunan Warrant Pharmaceutical Technology Development Co. Ltd. has disclosed data on the identification of a novel small-molecule inhibitor of Bruton tyrosine kinase (BTK), HND-01, which was identified by modifying metabolite 20 of dasatinib and is being developed for the potential treatment of cancer.

Cancer

Preclinical data presented for WNK inhibitor WNK-463

March 27, 2023

Researchers from LMU Munich discussed the role of WNK serine/threonine kinases 1 to 4 silencing in human prostate stromal WPMY-1 cells.

Substance Use & Poisoning

Toxicity data reported for VK-4-116 following once-daily oral dosing in rats and dogs

March 27, 2023

Researchers from the National Institutes of Health recently presented preclinical data for the dopamine D3 receptor antagonist VK-4-116, which has potential for the treatment of opioid use disorder (OUD).

Neurology/Psychiatric

EPI-321 gene therapy leads phenotypic rescue in humanized murine model of FSHD

March 24, 2023

Facioscapulohumeral muscular dystrophy (FSHD) is a skeletal muscular dystrophy characterized by DNA hypomethylation of D4Z4 repeat units of a macrosatellite array found at the distal end of chromosome region 4q35, which causes a myotoxic expression of DUX4. Researchers from Epic-Bio presented the discovery of EPI-321, a novel gene therapy candidate for the treatment of FSHD.

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Novel selective HPK1 inhibitors for cancer treatment disclosed

Sanofi presents selective CSF-1R inhibitor for the treatment of multiple sclerosis

Murine model study explores CAR T-cell efficacy and associated toxicity

New murine DMD model resembles the severe phenotype seen in humans

New opioid receptor modulator has the noncompetitive advantage

Atyr Pharma’s tRNA synthetase candidate ATYR-0101 binds to fibrosis target LTBP-1

Wild-type and C481S mutant BTK inhibitor HND-01 shows potent antitumoral activity

Preclinical data presented for WNK inhibitor WNK-463

Toxicity data reported for VK-4-116 following once-daily oral dosing in rats and dogs

EPI-321 gene therapy leads phenotypic rescue in humanized murine model of FSHD

Today's news in brief

News in brief

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