Accutar Biotechnology Inc. has patented new substituted quinoline derivatives acting as son of sevenless homolog 1 (SOS1) inhibitors reported to be useful for the treatment of cancer.
Signal transducer and activator of transcription 3 (STAT3) plays a key role in cell proliferation observed in colorectal cancer (CRC), where up-regulation of STAT3 accelerates tumorigenesis and promotes metastasis.
Oncopeptides AB has selected its first candidate drug based on the company’s unique platform for small polypeptide-based innate killer engagers (SPiKE). The SPiKE platform uses multispecific constructs, able to bind to multiple targets simultaneously.
Senescence is a hallmark of aging, and senescent cells have a reputation to match. They are ‘zombie cells,’ sort of dead themselves but alive enough to poison their surroundings through senescence-associated secretory phenotype (SASP). The reality, though, is more complex.
Janssen Pharmaceutica NV and Johnson & Johnson (China) Investment Ltd. patents disclose new menin (MEN1)/MLL interaction inhibitors reported to be useful for the treatment of cancer.
Gen1e Lifesciences Inc. has prepared new mitogen-activated protein kinase 14 (MAPK14; MAPK p38α) inhibitors reported to be useful for the treatment of cancer, inflammatory disorders, autoimmune diseases, viral infections, acute respiratory distress syndrome, amyotrophic lateral sclerosis, chronic obstructive pulmonary disease and cystic fibrosis.
Research at Idorsia Pharmaceuticals Ltd. has led to the discovery of aryl- and heteroaryl-sulfonamide derivatives acting as C-C chemokine receptor type 8 (CCR8) antagonists.
CAR T-cell therapy that targets BCMA is an effective option for treating relapsed/refractory multiple myeloma, but there is a lack of persistence due to the inability to develop a memory phenotype.
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